Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders
<p>Abstract</p> <p>Background</p> <p>The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis.</p> <p>Aims of the study</p> <p>To ex...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-05-01
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| Series: | Health and Quality of Life Outcomes |
| Online Access: | http://www.hqlo.com/content/8/1/47 |
| _version_ | 1811248541948968960 |
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| author | Heinrich Sven Matschinger Herbert Günther Oliver Born Anja König Hans-Helmut Riedel-Heller Steffi G Angermeyer Matthias C Roick Christiane |
| author_facet | Heinrich Sven Matschinger Herbert Günther Oliver Born Anja König Hans-Helmut Riedel-Heller Steffi G Angermeyer Matthias C Roick Christiane |
| author_sort | Heinrich Sven |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis.</p> <p>Aims of the study</p> <p>To examine validity and responsiveness of the EQ-5D in patients with anxiety disorders.</p> <p>Methods</p> <p>389 patients with anxiety disorders completed the EQ-5D at baseline and 6-month follow-up. Subjective measures of quality of life (WHOQOL-BREF) and psychopathology (BAI, BDI-II, BSQ, ACQ, MI) were used for comparison. Validity was analyzed by assessing associations between EQ-5D scores and related other scores. Responsiveness was analyzed by calculating effect sizes of differences in scores between baseline and follow-up for 3 groups indicating more, constant or less anxiety. Meaningful difference scores for shifting to less or more anxiety were derived by means of regression analysis.</p> <p>Results</p> <p>88.4% of respondents reported problems in at least one of the EQ-5D dimension at baseline; the mean EQ VAS score was 63.8. The EQ-5D dimension most consistently associated with the measures used for comparison was 'anxiety/depression'. EQ VAS and EQ-5D index scores were highly correlated (|r|>0.5) with scores of the WHOQOL-BREF dimensions 'physical', 'mental' and 'overall' as well as BAI and BDI-II. The EQ-5D index tended to be the most responsive score. Standardized meaningful difference scores were not significantly different between EQ VAS, EQ-5D index and measures used for comparison.</p> <p>Conclusions</p> <p>The EQ-5D seems to be reasonably valid and moderately responsive in patients with anxiety disorders. The EQ-5D index may be suitable for calculating QALYs in economic evaluation of health care interventions for patients with anxiety disorders.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN15716049</p> |
| first_indexed | 2024-04-12T15:29:54Z |
| format | Article |
| id | doaj.art-12f7b73fd8594401a1ccaaad41459dd3 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-04-12T15:29:54Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-12f7b73fd8594401a1ccaaad41459dd32022-12-22T03:27:09ZengBMCHealth and Quality of Life Outcomes1477-75252010-05-01814710.1186/1477-7525-8-47Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disordersHeinrich SvenMatschinger HerbertGünther OliverBorn AnjaKönig Hans-HelmutRiedel-Heller Steffi GAngermeyer Matthias CRoick Christiane<p>Abstract</p> <p>Background</p> <p>The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis.</p> <p>Aims of the study</p> <p>To examine validity and responsiveness of the EQ-5D in patients with anxiety disorders.</p> <p>Methods</p> <p>389 patients with anxiety disorders completed the EQ-5D at baseline and 6-month follow-up. Subjective measures of quality of life (WHOQOL-BREF) and psychopathology (BAI, BDI-II, BSQ, ACQ, MI) were used for comparison. Validity was analyzed by assessing associations between EQ-5D scores and related other scores. Responsiveness was analyzed by calculating effect sizes of differences in scores between baseline and follow-up for 3 groups indicating more, constant or less anxiety. Meaningful difference scores for shifting to less or more anxiety were derived by means of regression analysis.</p> <p>Results</p> <p>88.4% of respondents reported problems in at least one of the EQ-5D dimension at baseline; the mean EQ VAS score was 63.8. The EQ-5D dimension most consistently associated with the measures used for comparison was 'anxiety/depression'. EQ VAS and EQ-5D index scores were highly correlated (|r|>0.5) with scores of the WHOQOL-BREF dimensions 'physical', 'mental' and 'overall' as well as BAI and BDI-II. The EQ-5D index tended to be the most responsive score. Standardized meaningful difference scores were not significantly different between EQ VAS, EQ-5D index and measures used for comparison.</p> <p>Conclusions</p> <p>The EQ-5D seems to be reasonably valid and moderately responsive in patients with anxiety disorders. The EQ-5D index may be suitable for calculating QALYs in economic evaluation of health care interventions for patients with anxiety disorders.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN15716049</p>http://www.hqlo.com/content/8/1/47 |
| spellingShingle | Heinrich Sven Matschinger Herbert Günther Oliver Born Anja König Hans-Helmut Riedel-Heller Steffi G Angermeyer Matthias C Roick Christiane Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders Health and Quality of Life Outcomes |
| title | Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders |
| title_full | Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders |
| title_fullStr | Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders |
| title_full_unstemmed | Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders |
| title_short | Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders |
| title_sort | validity and responsiveness of the eq 5d in assessing and valuing health status in patients with anxiety disorders |
| url | http://www.hqlo.com/content/8/1/47 |
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