Programmed Adult Kidney Disease: Importance of Fetal Environment
The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.586290/full |
| _version_ | 1828402574892466176 |
|---|---|
| author | Rogério Argeri Fernanda Thomazini Débora Conte Kimura Lichtenecker Karina Thieme Maria do Carmo Franco Guiomar Nascimento Gomes |
| author_facet | Rogério Argeri Fernanda Thomazini Débora Conte Kimura Lichtenecker Karina Thieme Maria do Carmo Franco Guiomar Nascimento Gomes |
| author_sort | Rogério Argeri |
| collection | DOAJ |
| description | The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce epigenetic changes and lead to alterations in the expression of renal phenotype. In this review, we have explored the renal development and its functions, while focusing on the epigenetic findings and functional aspects of the renin-angiotensin system and its components. |
| first_indexed | 2024-12-10T10:03:09Z |
| format | Article |
| id | doaj.art-12faf185a5794f07866134a06ac9b2ea |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T10:03:09Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-12faf185a5794f07866134a06ac9b2ea2022-12-22T01:53:18ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.586290586290Programmed Adult Kidney Disease: Importance of Fetal EnvironmentRogério Argeri0Fernanda Thomazini1Débora Conte Kimura Lichtenecker2Karina Thieme3Maria do Carmo Franco4Guiomar Nascimento Gomes5Department of Physiology, School of Medicine, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, School of Medicine, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, School of Medicine, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, Universidade de Sao Paulo, São Paulo, BrazilDepartment of Physiology, School of Medicine, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, School of Medicine, Federal University of São Paulo, São Paulo, BrazilThe Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce epigenetic changes and lead to alterations in the expression of renal phenotype. In this review, we have explored the renal development and its functions, while focusing on the epigenetic findings and functional aspects of the renin-angiotensin system and its components.https://www.frontiersin.org/article/10.3389/fphys.2020.586290/fullrenal functionprogrammed kidney diseasehypertensionnephron numberfetal environment |
| spellingShingle | Rogério Argeri Fernanda Thomazini Débora Conte Kimura Lichtenecker Karina Thieme Maria do Carmo Franco Guiomar Nascimento Gomes Programmed Adult Kidney Disease: Importance of Fetal Environment Frontiers in Physiology renal function programmed kidney disease hypertension nephron number fetal environment |
| title | Programmed Adult Kidney Disease: Importance of Fetal Environment |
| title_full | Programmed Adult Kidney Disease: Importance of Fetal Environment |
| title_fullStr | Programmed Adult Kidney Disease: Importance of Fetal Environment |
| title_full_unstemmed | Programmed Adult Kidney Disease: Importance of Fetal Environment |
| title_short | Programmed Adult Kidney Disease: Importance of Fetal Environment |
| title_sort | programmed adult kidney disease importance of fetal environment |
| topic | renal function programmed kidney disease hypertension nephron number fetal environment |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.586290/full |
| work_keys_str_mv | AT rogerioargeri programmedadultkidneydiseaseimportanceoffetalenvironment AT fernandathomazini programmedadultkidneydiseaseimportanceoffetalenvironment AT deboracontekimuralichtenecker programmedadultkidneydiseaseimportanceoffetalenvironment AT karinathieme programmedadultkidneydiseaseimportanceoffetalenvironment AT mariadocarmofranco programmedadultkidneydiseaseimportanceoffetalenvironment AT guiomarnascimentogomes programmedadultkidneydiseaseimportanceoffetalenvironment |