Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature
Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production and/or enhancing their destruction from the...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2021-04-01
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| Series: | European Medical Journal |
| Online Access: | https://www.emjreviews.com/hematology/article/rifampicin-induced-thrombocytopenia-a-case-report-and-short-review-of-the-literature/ |
| _version_ | 1827275323131035648 |
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| author | Epameinondas Koumpis Konstantina Papathanasiou Ioannis Papakonstantinou Iliana Tassi Anastasia Serpanou Eleni Kapsali Eleftheria Hatzimichael |
| author_facet | Epameinondas Koumpis Konstantina Papathanasiou Ioannis Papakonstantinou Iliana Tassi Anastasia Serpanou Eleni Kapsali Eleftheria Hatzimichael |
| author_sort | Epameinondas Koumpis |
| collection | DOAJ |
| description |
Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production and/or enhancing their destruction from the peripheral blood mediated via an immunological mechanism implicating drug-dependent antibodies. The latter entity is called drug-induced immune thrombocytopenia: a life-threatening, under-recognised condition, which is often a diagnostic challenge. Rifampicin is a widely used, well-tolerated, and effective bactericidal drug. Adverse events, except for gastrointestinal effects, headache, skin rash, and pruritus, are uncommon. The authors herein report on a patient with isolated thrombocytopenia with a recent medical history of brucellosis on rifampicin and doxycycline. Thrombocytopenia was proved to be rifampicin-induced. Also presented is a short review of the literature on this rare subject, which should be of great importance to clinicians. |
| first_indexed | 2024-03-08T14:28:44Z |
| format | Article |
| id | doaj.art-12faf884c4074dbc92a2983e5e733172 |
| institution | Directory Open Access Journal |
| issn | 2397-6764 |
| language | English |
| last_indexed | 2025-03-22T06:39:04Z |
| publishDate | 2021-04-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal |
| spelling | doaj.art-12faf884c4074dbc92a2983e5e7331722024-04-24T09:01:36ZengEuropean Medical JournalEuropean Medical Journal2397-67642021-04-0110.33590/emj/20-00193Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the LiteratureEpameinondas Koumpis0Konstantina Papathanasiou1Ioannis Papakonstantinou2Iliana Tassi3Anastasia Serpanou4Eleni Kapsali5Eleftheria Hatzimichael6Department of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production and/or enhancing their destruction from the peripheral blood mediated via an immunological mechanism implicating drug-dependent antibodies. The latter entity is called drug-induced immune thrombocytopenia: a life-threatening, under-recognised condition, which is often a diagnostic challenge. Rifampicin is a widely used, well-tolerated, and effective bactericidal drug. Adverse events, except for gastrointestinal effects, headache, skin rash, and pruritus, are uncommon. The authors herein report on a patient with isolated thrombocytopenia with a recent medical history of brucellosis on rifampicin and doxycycline. Thrombocytopenia was proved to be rifampicin-induced. Also presented is a short review of the literature on this rare subject, which should be of great importance to clinicians.https://www.emjreviews.com/hematology/article/rifampicin-induced-thrombocytopenia-a-case-report-and-short-review-of-the-literature/ |
| spellingShingle | Epameinondas Koumpis Konstantina Papathanasiou Ioannis Papakonstantinou Iliana Tassi Anastasia Serpanou Eleni Kapsali Eleftheria Hatzimichael Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature European Medical Journal |
| title | Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature |
| title_full | Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature |
| title_fullStr | Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature |
| title_full_unstemmed | Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature |
| title_short | Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature |
| title_sort | rifampicin induced thrombocytopenia a case report and short review of the literature |
| url | https://www.emjreviews.com/hematology/article/rifampicin-induced-thrombocytopenia-a-case-report-and-short-review-of-the-literature/ |
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