Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.
Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evalua...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3760851?pdf=render |
| _version_ | 1828871194822049792 |
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| author | Jung Ryul Kim Young Jae Moon Keun Sang Kwon Jun Sang Bae Sajeev Wagle Taek Kyun Yu Kyoung Min Kim Ho Sung Park Ju-Hyung Lee Woo Sung Moon Ho Lee Myoung Ja Chung Kyu Yun Jang |
| author_facet | Jung Ryul Kim Young Jae Moon Keun Sang Kwon Jun Sang Bae Sajeev Wagle Taek Kyun Yu Kyoung Min Kim Ho Sung Park Ju-Hyung Lee Woo Sung Moon Ho Lee Myoung Ja Chung Kyu Yun Jang |
| author_sort | Jung Ryul Kim |
| collection | DOAJ |
| description | Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas.Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas. |
| first_indexed | 2024-12-13T06:27:46Z |
| format | Article |
| id | doaj.art-12fb0f9cb9ce4ac988d3ff6af6cb794d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T06:27:46Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-12fb0f9cb9ce4ac988d3ff6af6cb794d2022-12-21T23:56:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7473810.1371/journal.pone.0074738Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.Jung Ryul KimYoung Jae MoonKeun Sang KwonJun Sang BaeSajeev WagleTaek Kyun YuKyoung Min KimHo Sung ParkJu-Hyung LeeWoo Sung MoonHo LeeMyoung Ja ChungKyu Yun JangRecently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas.Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas.http://europepmc.org/articles/PMC3760851?pdf=render |
| spellingShingle | Jung Ryul Kim Young Jae Moon Keun Sang Kwon Jun Sang Bae Sajeev Wagle Taek Kyun Yu Kyoung Min Kim Ho Sung Park Ju-Hyung Lee Woo Sung Moon Ho Lee Myoung Ja Chung Kyu Yun Jang Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. PLoS ONE |
| title | Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. |
| title_full | Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. |
| title_fullStr | Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. |
| title_full_unstemmed | Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. |
| title_short | Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. |
| title_sort | expression of sirt1 and dbc1 is associated with poor prognosis of soft tissue sarcomas |
| url | http://europepmc.org/articles/PMC3760851?pdf=render |
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