RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Abstract Somatic and germline gain‐of‐function point mutations in RAF, one of the first oncogenes to be discovered in humans, delineate a group of tumor‐prone syndromes known as the RASopathies. In this study, we document the first human phenotype resulting from the germline loss‐of‐function of the...
| المؤلفون الرئيسيون: | , , , , , , , , , , |
|---|---|
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Springer Nature
2023-04-01
|
| سلاسل: | EMBO Molecular Medicine |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.15252/emmm.202217078 |