Methods to Produce Nicotinic Acid with Potential Industrial Applications
Nicotinic acid is a naturally occurring pyridine carboxylic acid, contained in vitamin PP, an essential nutrient for humans and animals, and used as an antipelagic agent. Nicotinic acid can be made from tryptophan by plants and animals but is usually not completely bioavailable. Industrially, nicoti...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/3/765 |
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| author | Dawid Lisicki Kinga Nowak Beata Orlińska |
| author_facet | Dawid Lisicki Kinga Nowak Beata Orlińska |
| author_sort | Dawid Lisicki |
| collection | DOAJ |
| description | Nicotinic acid is a naturally occurring pyridine carboxylic acid, contained in vitamin PP, an essential nutrient for humans and animals, and used as an antipelagic agent. Nicotinic acid can be made from tryptophan by plants and animals but is usually not completely bioavailable. Industrially, nicotinic acid is produced mainly by oxidation of 5-ethyl-2-methylpyridine with nitric acid. One of the by-products of the process is nitrous oxide, a gas that is difficult to recycle and manage, with a greenhouse effect 300 times stronger than CO<sub>2</sub>. A new technology for the industrial production of nicotinic acid is undoubtedly necessary to meet the needs of green chemistry and not burden the environment. We carried out a literature review on ecological methods to produce nicotinic acid from commercially available raw materials such as 3-methylpyridine and 5-ethyl-2-methylpyridine, especially focusing on those methods with potential industrial applications. |
| first_indexed | 2024-03-09T23:37:38Z |
| format | Article |
| id | doaj.art-12fcd4ab8b0645789c29aa5a13e76d2c |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T23:37:38Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-12fcd4ab8b0645789c29aa5a13e76d2c2023-11-23T16:56:48ZengMDPI AGMaterials1996-19442022-01-0115376510.3390/ma15030765Methods to Produce Nicotinic Acid with Potential Industrial ApplicationsDawid Lisicki0Kinga Nowak1Beata Orlińska2Department of Organic Chemical Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, PolandDepartment of Organic Chemical Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, PolandDepartment of Organic Chemical Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, PolandNicotinic acid is a naturally occurring pyridine carboxylic acid, contained in vitamin PP, an essential nutrient for humans and animals, and used as an antipelagic agent. Nicotinic acid can be made from tryptophan by plants and animals but is usually not completely bioavailable. Industrially, nicotinic acid is produced mainly by oxidation of 5-ethyl-2-methylpyridine with nitric acid. One of the by-products of the process is nitrous oxide, a gas that is difficult to recycle and manage, with a greenhouse effect 300 times stronger than CO<sub>2</sub>. A new technology for the industrial production of nicotinic acid is undoubtedly necessary to meet the needs of green chemistry and not burden the environment. We carried out a literature review on ecological methods to produce nicotinic acid from commercially available raw materials such as 3-methylpyridine and 5-ethyl-2-methylpyridine, especially focusing on those methods with potential industrial applications.https://www.mdpi.com/1996-1944/15/3/765nicotinic acidoxidationpicolinegreen chemistryindustrial synthesis |
| spellingShingle | Dawid Lisicki Kinga Nowak Beata Orlińska Methods to Produce Nicotinic Acid with Potential Industrial Applications Materials nicotinic acid oxidation picoline green chemistry industrial synthesis |
| title | Methods to Produce Nicotinic Acid with Potential Industrial Applications |
| title_full | Methods to Produce Nicotinic Acid with Potential Industrial Applications |
| title_fullStr | Methods to Produce Nicotinic Acid with Potential Industrial Applications |
| title_full_unstemmed | Methods to Produce Nicotinic Acid with Potential Industrial Applications |
| title_short | Methods to Produce Nicotinic Acid with Potential Industrial Applications |
| title_sort | methods to produce nicotinic acid with potential industrial applications |
| topic | nicotinic acid oxidation picoline green chemistry industrial synthesis |
| url | https://www.mdpi.com/1996-1944/15/3/765 |
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