Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm
Abstract Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-021-00241-2 |
| _version_ | 1819024758824501248 |
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| author | Haotian Zhang Melissa Castiglione Lei Zheng Huichun Zhan |
| author_facet | Haotian Zhang Melissa Castiglione Lei Zheng Huichun Zhan |
| author_sort | Haotian Zhang |
| collection | DOAJ |
| description | Abstract Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN relapse, in which ~ 60% of the MPN recipient mice develop disease relapse after receiving stem cell transplantation with wild-type marrow donor. Using this model, we find that impaired wild-type cell function is associated with MPN disease relapse. We also show that competition between wild-type and JAK2V617F mutant cells can modulate the immune cell composition and PD-L1 expression induced by the JAK2V617F oncogene. These results suggest that cell competition between wild-type donor cells and JAK2V617F mutant recipient cells can prevent MPN disease relapse after stem cell transplantation. |
| first_indexed | 2024-12-21T04:59:53Z |
| format | Article |
| id | doaj.art-1300f9d68d2a4c9fb4e5ee1741cc1345 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-21T04:59:53Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-1300f9d68d2a4c9fb4e5ee1741cc13452022-12-21T19:15:16ZengBMCExperimental Hematology & Oncology2162-36192021-10-011011410.1186/s40164-021-00241-2Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasmHaotian Zhang0Melissa Castiglione1Lei Zheng2Huichun Zhan3Graduate Program in Molecular and Cellular Biology, Stony Brook UniversityDepartment of Medicine, Stony Brook School of MedicineThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins UniversityDepartment of Medicine, Stony Brook School of MedicineAbstract Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN relapse, in which ~ 60% of the MPN recipient mice develop disease relapse after receiving stem cell transplantation with wild-type marrow donor. Using this model, we find that impaired wild-type cell function is associated with MPN disease relapse. We also show that competition between wild-type and JAK2V617F mutant cells can modulate the immune cell composition and PD-L1 expression induced by the JAK2V617F oncogene. These results suggest that cell competition between wild-type donor cells and JAK2V617F mutant recipient cells can prevent MPN disease relapse after stem cell transplantation.https://doi.org/10.1186/s40164-021-00241-2Myeloproliferative neoplasmStem cell transplantationRelapseCell competitionJAK2V617FImmune cells |
| spellingShingle | Haotian Zhang Melissa Castiglione Lei Zheng Huichun Zhan Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm Experimental Hematology & Oncology Myeloproliferative neoplasm Stem cell transplantation Relapse Cell competition JAK2V617F Immune cells |
| title | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| title_full | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| title_fullStr | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| title_full_unstemmed | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| title_short | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| title_sort | cell competition between wild type and jak2v617f mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
| topic | Myeloproliferative neoplasm Stem cell transplantation Relapse Cell competition JAK2V617F Immune cells |
| url | https://doi.org/10.1186/s40164-021-00241-2 |
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