Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm

Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm

Abstract Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model o...

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Bibliographic Details
Main Authors: Haotian Zhang, Melissa Castiglione, Lei Zheng, Huichun Zhan
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Experimental Hematology & Oncology
Subjects:
Myeloproliferative neoplasm
Stem cell transplantation
Relapse
Cell competition
JAK2V617F
Immune cells
Online Access:https://doi.org/10.1186/s40164-021-00241-2

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