P822: A PHASE 1 SINGLE ASCENDING DOSE STUDY OF CAN106, A LONG-ACTING ANTI-C5 COMPLEMENT MONOCLONAL ANTIBODY IN CLINICAL DEVELOPMENT FOR PNH AND OTHER COMPLEMENT-MEDIATED DISEASES

P822: A PHASE 1 SINGLE ASCENDING DOSE STUDY OF CAN106, A LONG-ACTING ANTI-C5 COMPLEMENT MONOCLONAL ANTIBODY IN CLINICAL DEVELOPMENT FOR PNH AND OTHER COMPLEMENT-MEDIATED DISEASES

Bibliographic Details
Main Authors:	C. M. KHOO, X. SONG, Q. WU, G. F. COX
Format:	Article
Language:	English
Published:	Wiley 2022-06-01
Series:	HemaSphere
Online Access:	http://journals.lww.com/10.1097/01.HS9.0000846172.64321.0a

Similar Items

Pegcetacoplan: A New Opportunity for Complement Inhibition in PNH
by: Weitz IC
Published: (2023-03-01)

P791: COMMON VARIANTS IN COMPLEMENT PROTEINS, C3 AND CR1, ENHANCE COMPLEMENT ATTACK ON PNH ERYTHROCYTES AND INCREASE RISK FOR EXTRAVASCULAR HAEMOLYSIS
by: A. J. Baral, et al.
Published: (2022-06-01)

Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
by: Bindon, C, et al.
Published: (1988)

Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
by: Cobbold, S, et al.
Published: (1990)

Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
by: Cobbold, S, et al.
Published: (1990)

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.
by: Sunita Gulati, et al.
Published: (2019-06-01)

Postfoundational practical theology as public Christol̶o̶g̶y̶
by: Johann-Albrecht Meylahn
Published: (2014-08-01)

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
by: Wioleta M. Zelek, et al.
Published: (2020-12-01)

P774: SUBSTANTIAL INCREASES IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) RED BLOOD CELL CLONE SIZE WITH ORAL IPTACOPAN MONOTHERAPY CONFIRMS CONTROL OF HEMOLYSIS IN COMPLEMENT INHIBITOR-NAÏVE PNH PATIENTS
by: Régis Peffault de Latour, et al.
Published: (2023-08-01)

Monoclonal antibody targeting complement C9 binding domain of Trichinella spiralis paramyosin impairs the viability of Trichinella infective larvae in the presence of complement
by: Yuwan Hao, et al.
Published: (2014-07-01)

MONOCLONAL-ANTIBODY SUPPRESSION OF GRAFT-VS-HOST REACTION WITHOUT THE NEED FOR COMPLEMENT OR RICIN
by: Okunewick, J, et al.
Published: (1984)

Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affinity
by: Mizutani Nobuaki, et al.
Published: (2011-11-01)

PB2057: THE COMBINATION OF ANTI-COMPLEMENT THERAPY AND CYCLOSPORINE +/- ELTROMBOPAG IN PNH IS EFFECTIVE AND SAFE: A REAL-LIFE OBSERVATIONAL STUDY.
by: Federica Catania, et al.
Published: (2023-08-01)

Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis.
by: Bindon, C, et al.
Published: (1985)

Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma
by: Lisanne de Vor, et al.
Published: (2022-07-01)

Can Nondeterminism Help Complementation?
by: Yang Cai, et al.
Published: (2012-10-01)

Clinical Frailty Scale and the FRAIL checklist: Can they complement each other?
by: Emmanuel Hei-Lok Cheung, et al.
Published: (2023-05-01)

Monoclonal immunoglobulin mediates complement activation in monoclonal gammopathy associated-C3 glomerulonephritis
by: Lin-Lin Li, et al.
Published: (2019-12-01)

Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement.
by: Hale, G, et al.
Published: (1983)

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
by: Leon Cyranka, et al.
Published: (2023-11-01)

Can complement fix placental malaria?
by: Justin Y. A. Doritchamou, et al.
Published: (2021-09-01)

A Phase I, Single Ascending Dose Study of GEM103 (Recombinant Human Complement Factor H) in Patients with Geographic Atrophy
by: Arshad M. Khanani, MD, MA, et al.
Published: (2022-06-01)

Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.
by: Bindon, C, et al.
Published: (1987)

Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
by: Hale, G, et al.
Published: (1986)

In Silico Designed Gain-of-Function Variants of Complement C2 Support Cytocidal Activity of Anticancer Monoclonal Antibodies
by: Aleksandra Urban, et al.
Published: (2022-03-01)

Infusion Reactions Associated with the Medical Application of Monoclonal Antibodies: The Role of Complement Activation and Possibility of Inhibition by Factor H
by: Tamás Fülöp, et al.
Published: (2018-03-01)

Complementizer Drop And IP Complementation in Japanese
by: Fukuda, Minoru
Published: (2000-01-01)

Complement in Non-Antibody-Mediated Kidney Diseases
by: Andrea Angeletti, et al.
Published: (2017-07-01)

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.
by: Adrianna Latuszek, et al.
Published: (2020-01-01)

A humanized monovalent CD3 antibody which can activate homologous complement.
by: Routledge, E, et al.
Published: (1991)

Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination
by: Patrick Peschl, et al.
Published: (2017-10-01)

Vascular Diseases in PNH
by: Hanan Hamed
Published: (2022-10-01)

A monoclonal antibody against human complement component C3: the production of C3 by human cells in vitro.
by: Whitehead, A, et al.
Published: (1981)

Complement sentences - complementizers of causative-manipulative verbs
by: Alanović Milivoj B.
Published: (2015-01-01)

Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing.
by: Griffin, R, et al.
Published: (2005)

Both Monoclonal and Polyclonal Immunoglobulin Contingents Mediate Complement Activation in Monoclonal Gammopathy Associated-C3 Glomerulopathy
by: Sophie Chauvet, et al.
Published: (2018-10-01)

Advanced Body Measurement Techniques Can Complement Current Methods of Cytotoxic Chemotherapy Dose Prescription
by: Michael Thelwell, et al.
Published: (2024-01-01)

Functional Complement Analysis Can Predict Genetic Testing Results and Long-Term Outcome in Patients With Complement Deficiencies
by: Štefan Blazina, et al.
Published: (2018-03-01)

The essential role of complement in antibody-mediated resistance to Salmonella
by: Rossi, O, et al.
Published: (2018)

24 The role of complement and complement inhibition in APS pregnancy
by: Jane Salmon
Published: (2021-04-01)