Towards Personalized Therapy of Aortic Stenosis
Calcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease in adults with no available pharmacological treatment to inhibit the disease progression to date. This review provides an up-to-date overview of current knowledge of molecular mechanisms underlying CAS pathobi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/12/1292 |
| _version_ | 1797503091750207488 |
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| author | Piotr Mazur Magdalena Kopytek Michał Ząbczyk Anetta Undas Joanna Natorska |
| author_facet | Piotr Mazur Magdalena Kopytek Michał Ząbczyk Anetta Undas Joanna Natorska |
| author_sort | Piotr Mazur |
| collection | DOAJ |
| description | Calcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease in adults with no available pharmacological treatment to inhibit the disease progression to date. This review provides an up-to-date overview of current knowledge of molecular mechanisms underlying CAS pathobiology and the related treatment pathways. Particular attention is paid to current randomized trials investigating medical treatment of CAS, including strategies based on lipid-lowering and antihypertensive therapies, phosphate and calcium metabolism, and novel therapeutic targets such as valvular oxidative stress, coagulation proteins, matrix metalloproteinases, and accumulation of advanced glycation end products. |
| first_indexed | 2024-03-10T03:45:34Z |
| format | Article |
| id | doaj.art-1303d6469f1f45b08b9d896354833d90 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:45:34Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1303d6469f1f45b08b9d896354833d902023-11-23T09:07:29ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112129210.3390/jpm11121292Towards Personalized Therapy of Aortic StenosisPiotr Mazur0Magdalena Kopytek1Michał Ząbczyk2Anetta Undas3Joanna Natorska4Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55902, USAInstitute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31-202 Kraków, PolandInstitute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31-202 Kraków, PolandInstitute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31-202 Kraków, PolandInstitute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31-202 Kraków, PolandCalcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease in adults with no available pharmacological treatment to inhibit the disease progression to date. This review provides an up-to-date overview of current knowledge of molecular mechanisms underlying CAS pathobiology and the related treatment pathways. Particular attention is paid to current randomized trials investigating medical treatment of CAS, including strategies based on lipid-lowering and antihypertensive therapies, phosphate and calcium metabolism, and novel therapeutic targets such as valvular oxidative stress, coagulation proteins, matrix metalloproteinases, and accumulation of advanced glycation end products.https://www.mdpi.com/2075-4426/11/12/1292calcific aortic stenosisnon-vitamin K antagonist oral anticoagulantsadvanced glycation end productstissue inhibitors of matrix metalloproteinasesinflammationcalcification |
| spellingShingle | Piotr Mazur Magdalena Kopytek Michał Ząbczyk Anetta Undas Joanna Natorska Towards Personalized Therapy of Aortic Stenosis Journal of Personalized Medicine calcific aortic stenosis non-vitamin K antagonist oral anticoagulants advanced glycation end products tissue inhibitors of matrix metalloproteinases inflammation calcification |
| title | Towards Personalized Therapy of Aortic Stenosis |
| title_full | Towards Personalized Therapy of Aortic Stenosis |
| title_fullStr | Towards Personalized Therapy of Aortic Stenosis |
| title_full_unstemmed | Towards Personalized Therapy of Aortic Stenosis |
| title_short | Towards Personalized Therapy of Aortic Stenosis |
| title_sort | towards personalized therapy of aortic stenosis |
| topic | calcific aortic stenosis non-vitamin K antagonist oral anticoagulants advanced glycation end products tissue inhibitors of matrix metalloproteinases inflammation calcification |
| url | https://www.mdpi.com/2075-4426/11/12/1292 |
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