Tocotrienols as an Anti-Breast Cancer Agent

In the past few years, breast cancer has become the most prevalent type of cancer. The majority of patients receive combinatorial chemotherapy treatments, which may result in increased risk of developing drug resistance, a reduced quality of life, and substantial side effects. Treatment modalities t...

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Main Authors: Madison Trujillo, Anupreet Kharbanda, Christa Corley, Pilar Simmons, Antiño R. Allen
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/9/1383
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author Madison Trujillo
Anupreet Kharbanda
Christa Corley
Pilar Simmons
Antiño R. Allen
author_facet Madison Trujillo
Anupreet Kharbanda
Christa Corley
Pilar Simmons
Antiño R. Allen
author_sort Madison Trujillo
collection DOAJ
description In the past few years, breast cancer has become the most prevalent type of cancer. The majority of patients receive combinatorial chemotherapy treatments, which may result in increased risk of developing drug resistance, a reduced quality of life, and substantial side effects. Treatment modalities that could lessen the physical toll of standard treatments or act in synergy with chemotherapeutic treatments would benefit women worldwide. Research into tocotrienols has thus far demonstrated their potential to be such an agent, with tocotrienols surpassing the pharmacological potential of tocopherols. Further research using in vitro and preclinical breast cancer models to support clinical trials is needed. This review uses bibliometric analysis to highlight this gap in research and summarizes the current and future landscape of tocotrienols as an anti-breast cancer agent.
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spelling doaj.art-13040bcdce784dd5ae3d9c35f611e80b2023-11-22T11:47:55ZengMDPI AGAntioxidants2076-39212021-08-01109138310.3390/antiox10091383Tocotrienols as an Anti-Breast Cancer AgentMadison Trujillo0Anupreet Kharbanda1Christa Corley2Pilar Simmons3Antiño R. Allen4Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADepartment of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAIn the past few years, breast cancer has become the most prevalent type of cancer. The majority of patients receive combinatorial chemotherapy treatments, which may result in increased risk of developing drug resistance, a reduced quality of life, and substantial side effects. Treatment modalities that could lessen the physical toll of standard treatments or act in synergy with chemotherapeutic treatments would benefit women worldwide. Research into tocotrienols has thus far demonstrated their potential to be such an agent, with tocotrienols surpassing the pharmacological potential of tocopherols. Further research using in vitro and preclinical breast cancer models to support clinical trials is needed. This review uses bibliometric analysis to highlight this gap in research and summarizes the current and future landscape of tocotrienols as an anti-breast cancer agent.https://www.mdpi.com/2076-3921/10/9/1383tocotrienolsbreast cancerγ-tocotrienolδ-tocotrienolnatural adjuvantanti-cancer
spellingShingle Madison Trujillo
Anupreet Kharbanda
Christa Corley
Pilar Simmons
Antiño R. Allen
Tocotrienols as an Anti-Breast Cancer Agent
Antioxidants
tocotrienols
breast cancer
γ-tocotrienol
δ-tocotrienol
natural adjuvant
anti-cancer
title Tocotrienols as an Anti-Breast Cancer Agent
title_full Tocotrienols as an Anti-Breast Cancer Agent
title_fullStr Tocotrienols as an Anti-Breast Cancer Agent
title_full_unstemmed Tocotrienols as an Anti-Breast Cancer Agent
title_short Tocotrienols as an Anti-Breast Cancer Agent
title_sort tocotrienols as an anti breast cancer agent
topic tocotrienols
breast cancer
γ-tocotrienol
δ-tocotrienol
natural adjuvant
anti-cancer
url https://www.mdpi.com/2076-3921/10/9/1383
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AT anupreetkharbanda tocotrienolsasanantibreastcanceragent
AT christacorley tocotrienolsasanantibreastcanceragent
AT pilarsimmons tocotrienolsasanantibreastcanceragent
AT antinorallen tocotrienolsasanantibreastcanceragent