Synthesis and gastric ulcer protective activity of chlorinated quercetin
Gastrointestinal toxicity due to non-steroid anti-inflammatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against gastric ulcer. Chlorination of quercetin enhanced the antioxidant activity. This...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2009-12-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/524 |
| _version_ | 1819080502067331072 |
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| author | Tutus Gusdinar Rina Herowati, R. E. Kartasasmita I Ketut Adnyana |
| author_facet | Tutus Gusdinar Rina Herowati, R. E. Kartasasmita I Ketut Adnyana |
| author_sort | Tutus Gusdinar |
| collection | DOAJ |
| description | Gastrointestinal toxicity due to non-steroid anti-inflammatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against gastric ulcer. Chlorination of quercetin enhanced the antioxidant activity. This study aims to obtain the chlorinated derivative of quercetin and examine the protection effect against acetosal-induced gastric ulcer. Chlorination was done by the addition of chlorine at room temperature. Ulcer induction was carried out on rats by oral administration of acetosal. Incidences of gastric ulcer were determined by macroscopic and microscopic observation. Chlorination of quercetin with chlorine gas produced 6-chloroqueretin as major product. The protection effect against acetosal-induced gastric ulcer of this compound was higher than quercetin. |
| first_indexed | 2024-12-21T19:45:54Z |
| format | Article |
| id | doaj.art-1304e0b9b495411f8ef54f06a42695f4 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-21T19:45:54Z |
| publishDate | 2009-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-1304e0b9b495411f8ef54f06a42695f42022-12-21T18:52:20ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862009-12-01204163169Synthesis and gastric ulcer protective activity of chlorinated quercetinTutus Gusdinar0Rina Herowati, 1R. E. Kartasasmita2 I Ketut Adnyana3Sekolah Farmasi ITB, Jl. Ganesha 10 BandungSekolah Farmasi ITB, Jl. Ganesha 10 BandungSekolah Farmasi ITB, Jl. Ganesha 10 BandungSekolah Farmasi ITB, Jl. Ganesha 10 BandungGastrointestinal toxicity due to non-steroid anti-inflammatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against gastric ulcer. Chlorination of quercetin enhanced the antioxidant activity. This study aims to obtain the chlorinated derivative of quercetin and examine the protection effect against acetosal-induced gastric ulcer. Chlorination was done by the addition of chlorine at room temperature. Ulcer induction was carried out on rats by oral administration of acetosal. Incidences of gastric ulcer were determined by macroscopic and microscopic observation. Chlorination of quercetin with chlorine gas produced 6-chloroqueretin as major product. The protection effect against acetosal-induced gastric ulcer of this compound was higher than quercetin.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/524quercetinchlorinationgastric ulcerNSAIDs |
| spellingShingle | Tutus Gusdinar Rina Herowati, R. E. Kartasasmita I Ketut Adnyana Synthesis and gastric ulcer protective activity of chlorinated quercetin Indonesian Journal of Pharmacy quercetin chlorination gastric ulcer NSAIDs |
| title | Synthesis and gastric ulcer protective activity of chlorinated quercetin |
| title_full | Synthesis and gastric ulcer protective activity of chlorinated quercetin |
| title_fullStr | Synthesis and gastric ulcer protective activity of chlorinated quercetin |
| title_full_unstemmed | Synthesis and gastric ulcer protective activity of chlorinated quercetin |
| title_short | Synthesis and gastric ulcer protective activity of chlorinated quercetin |
| title_sort | synthesis and gastric ulcer protective activity of chlorinated quercetin |
| topic | quercetin chlorination gastric ulcer NSAIDs |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/524 |
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