Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients
Purpose: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Blood Pressure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08037051.2017.1346459 |
| _version_ | 1797685122017787904 |
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| author | Ingjerd W. Manner Bård Waldum-Grevbo Birgit Nomeland Witczak Morten Bækken Olav Øktedalen Ingrid Os Thomas Schwartz Ivar Sjaastad |
| author_facet | Ingjerd W. Manner Bård Waldum-Grevbo Birgit Nomeland Witczak Morten Bækken Olav Øktedalen Ingrid Os Thomas Schwartz Ivar Sjaastad |
| author_sort | Ingjerd W. Manner |
| collection | DOAJ |
| description | Purpose: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function. Materials and methods: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography. Results: Non-dipping nocturnal BP pattern was present in 51% of the patients. Decreased nocturnal decline in systolic BP (SBP) correlated with lower CD4 count (rsp = 0.21, p = 0.032) and lower CD4/CD8 ratio (rsp = 0.26, p = 0.008). In multivariate linear regression analyses, lower BMI (p = 0.015) and CD4/CD8 ratio <0.4 (p = 0.010) remained independent predictors of nocturnal decline in SBP. Nocturnal decline in SBP correlated with impaired diastolic function, e’ (r = 0.28, p = 0.049) as did nadir CD4 count (rsp = 0.38, p = 0.006). In multivariate linear regression analyses, nadir CD4 count <100 cells/μL (p = 0.037) and age (p < 0.001) remained independent predictors of e’. Conclusions: Compromised immune status may contribute to attenuated diurnal BP profile as well as impaired diastolic function in well-treated HIV infection. |
| first_indexed | 2024-03-12T00:39:49Z |
| format | Article |
| id | doaj.art-1307154fbd294ef29500fffb85a378f4 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:49Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-1307154fbd294ef29500fffb85a378f42023-09-15T08:45:21ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992017-11-0126633234010.1080/08037051.2017.13464591346459Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patientsIngjerd W. Manner0Bård Waldum-Grevbo1Birgit Nomeland Witczak2Morten Bækken3Olav Øktedalen4Ingrid Os5Thomas Schwartz6Ivar Sjaastad7Oslo University HospitalOslo University HospitalOslo University Hospital and University of OsloOslo University HospitalOslo University HospitalOslo University HospitalOslo University Hospital and University of OsloOslo University Hospital and University of OsloPurpose: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function. Materials and methods: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography. Results: Non-dipping nocturnal BP pattern was present in 51% of the patients. Decreased nocturnal decline in systolic BP (SBP) correlated with lower CD4 count (rsp = 0.21, p = 0.032) and lower CD4/CD8 ratio (rsp = 0.26, p = 0.008). In multivariate linear regression analyses, lower BMI (p = 0.015) and CD4/CD8 ratio <0.4 (p = 0.010) remained independent predictors of nocturnal decline in SBP. Nocturnal decline in SBP correlated with impaired diastolic function, e’ (r = 0.28, p = 0.049) as did nadir CD4 count (rsp = 0.38, p = 0.006). In multivariate linear regression analyses, nadir CD4 count <100 cells/μL (p = 0.037) and age (p < 0.001) remained independent predictors of e’. Conclusions: Compromised immune status may contribute to attenuated diurnal BP profile as well as impaired diastolic function in well-treated HIV infection.http://dx.doi.org/10.1080/08037051.2017.1346459hiv infectioncd4/cd8 rationadir cd4 lymphocyte countnon-dipping blood pressure patternechocardiographydiastolic dysfunction |
| spellingShingle | Ingjerd W. Manner Bård Waldum-Grevbo Birgit Nomeland Witczak Morten Bækken Olav Øktedalen Ingrid Os Thomas Schwartz Ivar Sjaastad Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients Blood Pressure hiv infection cd4/cd8 ratio nadir cd4 lymphocyte count non-dipping blood pressure pattern echocardiography diastolic dysfunction |
| title | Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients |
| title_full | Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients |
| title_fullStr | Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients |
| title_full_unstemmed | Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients |
| title_short | Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients |
| title_sort | immune markers diurnal blood pressure profile and cardiac function in virologically suppressed hiv infected patients |
| topic | hiv infection cd4/cd8 ratio nadir cd4 lymphocyte count non-dipping blood pressure pattern echocardiography diastolic dysfunction |
| url | http://dx.doi.org/10.1080/08037051.2017.1346459 |
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