Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits
<b>AIM:</b>To evaluate the efficacy of Seprafilm<sup>®</sup> transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes.<b>METHODS:</b>Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits....
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2013-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580248/ |
| _version_ | 1828162838814785536 |
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| author | Sang Wook Jin |
| author_facet | Sang Wook Jin |
| author_sort | Sang Wook Jin |
| collection | DOAJ |
| description | <b>AIM:</b>To evaluate the efficacy of Seprafilm<sup>®</sup> transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes.<b>METHODS:</b>Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made, and adhesiolysis was performed on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in the left eyelid (control group), and the other with adhesiolysis with a Seprafilm<sup>®</sup> graft in the right eyelid (Seprafilm<sup>®</sup> group). The degrees of inflammation and fibrosis were examined with hematoxylin-eosin (HE) and Masson’s trichrome stains. Expression of α-smooth muscle actin (α-SMA) was also immunohistochemically examined.<b>RESULTS:</b>Eyelid examination immediately after the operation revealed mild swelling and hemorrhage in both groups, but these symptoms resolved after 1 week-2 weeks, and eyelid shape had recovered completely in both groups. Microscopic assessments demonstrated that the Seprafilm<sup>®</sup> group showed less inflammation and fibrosis than the control group. The Seprafilm<sup>®</sup> group also exhibited fewer α-SMA-positive cells than the control group.<b>CONCLUSION:</b>Based on these findings, we conclude that Seprafilm<sup>®</sup> graft with adhesiolysis is an effective method for preventing postoperative readhesions after eyelid surgery. |
| first_indexed | 2024-04-12T01:01:55Z |
| format | Article |
| id | doaj.art-130786aa45ea43e4826fc38217bd26c9 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T01:01:55Z |
| publishDate | 2013-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-130786aa45ea43e4826fc38217bd26c92022-12-22T03:54:25ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982013-02-0161444910.3980/j.issn.2222-3959.2013.01.09Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbitsSang Wook Jin<b>AIM:</b>To evaluate the efficacy of Seprafilm<sup>®</sup> transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes.<b>METHODS:</b>Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made, and adhesiolysis was performed on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in the left eyelid (control group), and the other with adhesiolysis with a Seprafilm<sup>®</sup> graft in the right eyelid (Seprafilm<sup>®</sup> group). The degrees of inflammation and fibrosis were examined with hematoxylin-eosin (HE) and Masson’s trichrome stains. Expression of α-smooth muscle actin (α-SMA) was also immunohistochemically examined.<b>RESULTS:</b>Eyelid examination immediately after the operation revealed mild swelling and hemorrhage in both groups, but these symptoms resolved after 1 week-2 weeks, and eyelid shape had recovered completely in both groups. Microscopic assessments demonstrated that the Seprafilm<sup>®</sup> group showed less inflammation and fibrosis than the control group. The Seprafilm<sup>®</sup> group also exhibited fewer α-SMA-positive cells than the control group.<b>CONCLUSION:</b>Based on these findings, we conclude that Seprafilm<sup>®</sup> graft with adhesiolysis is an effective method for preventing postoperative readhesions after eyelid surgery.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580248/Seprafilm<sup>®</sup>adhesionadhesiolysis |
| spellingShingle | Sang Wook Jin Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits International Journal of Ophthalmology Seprafilm<sup>®</sup> adhesion adhesiolysis |
| title | Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| title_full | Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| title_fullStr | Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| title_full_unstemmed | Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| title_short | Efficacy of Seprafilm<sup>®</sup> graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| title_sort | efficacy of seprafilm sup r sup graft with adhesiolysis in experimentally induced lid adhesion in rabbits |
| topic | Seprafilm<sup>®</sup> adhesion adhesiolysis |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580248/ |
| work_keys_str_mv | AT sangwookjin efficacyofseprafilmsupsupgraftwithadhesiolysisinexperimentallyinducedlidadhesioninrabbits |