Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer
Abstract Background Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identifying some biomarkers for early diagnosis, prediction of prognosis and...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-10336-6 |
| _version_ | 1811304463799943168 |
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| author | Sai Li Sifu Yang Yupeng Hong |
| author_facet | Sai Li Sifu Yang Yupeng Hong |
| author_sort | Sai Li |
| collection | DOAJ |
| description | Abstract Background Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identifying some biomarkers for early diagnosis, prediction of prognosis and disease monitoring. TOX, a critical transcription factor related to the development of malignancies that contributing to lymphocytes not just T cells, had been proved prognostic value in some spectrum of cancers. Here, we aimed to study the prognostic role of TOX in ovarian cancer. Results We found that TOX was not only expressed in CD8 T cells but also tumor cells. TOX expression score was higher in ovarian cancer tissues and correlated with survival status. Survival analysis revealed that ovarian cancer patients with high TOX expression score generally shorter overall survival and disease-free survival times. Univariate and Multivariate Cox demonstrated that TOX expression score could be used as an independent prognostic factor for patients with ovarian cancer. Conclusion TOX expression in ovarian cancer could be a promising tool for predict overall survival of ovarian cancer patients. |
| first_indexed | 2024-04-13T08:06:30Z |
| format | Article |
| id | doaj.art-1308c3b89d3742debd511868105482c8 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T08:06:30Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-1308c3b89d3742debd511868105482c82022-12-22T02:55:07ZengBMCBMC Cancer1471-24072022-11-012211910.1186/s12885-022-10336-6Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancerSai Li0Sifu Yang1Yupeng Hong2Department of gynecologic oncology, Women’s Hospital, Zhejiang University school of medicineCancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Background Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identifying some biomarkers for early diagnosis, prediction of prognosis and disease monitoring. TOX, a critical transcription factor related to the development of malignancies that contributing to lymphocytes not just T cells, had been proved prognostic value in some spectrum of cancers. Here, we aimed to study the prognostic role of TOX in ovarian cancer. Results We found that TOX was not only expressed in CD8 T cells but also tumor cells. TOX expression score was higher in ovarian cancer tissues and correlated with survival status. Survival analysis revealed that ovarian cancer patients with high TOX expression score generally shorter overall survival and disease-free survival times. Univariate and Multivariate Cox demonstrated that TOX expression score could be used as an independent prognostic factor for patients with ovarian cancer. Conclusion TOX expression in ovarian cancer could be a promising tool for predict overall survival of ovarian cancer patients.https://doi.org/10.1186/s12885-022-10336-6Ovarian cancerTOXCD8 + T cellPrognosis |
| spellingShingle | Sai Li Sifu Yang Yupeng Hong Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer BMC Cancer Ovarian cancer TOX CD8 + T cell Prognosis |
| title | Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer |
| title_full | Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer |
| title_fullStr | Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer |
| title_full_unstemmed | Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer |
| title_short | Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer |
| title_sort | higher thymocyte selection associated high mobility group box tox expression predicts poor prognosis in patients with ovarian cancer |
| topic | Ovarian cancer TOX CD8 + T cell Prognosis |
| url | https://doi.org/10.1186/s12885-022-10336-6 |
| work_keys_str_mv | AT saili higherthymocyteselectionassociatedhighmobilitygroupboxtoxexpressionpredictspoorprognosisinpatientswithovariancancer AT sifuyang higherthymocyteselectionassociatedhighmobilitygroupboxtoxexpressionpredictspoorprognosisinpatientswithovariancancer AT yupenghong higherthymocyteselectionassociatedhighmobilitygroupboxtoxexpressionpredictspoorprognosisinpatientswithovariancancer |