Are antidepressants addictive? a literature review
Introduction Nowadays, the rates of antidepressant prescription are high and increasing. In this context, the issue of whether these medications are addictive has been increasingly discussed. Objectives The aim of this review was to explore the debate about the addictive property of antidepressants...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823013998/type/journal_article |
| _version_ | 1797617178568032256 |
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| author | M. Turki O. Elleuch F. Sahnoun H. E. Mhiri A. Guermazi S. Ellouze N. Halouani J. Aloulou |
| author_facet | M. Turki O. Elleuch F. Sahnoun H. E. Mhiri A. Guermazi S. Ellouze N. Halouani J. Aloulou |
| author_sort | M. Turki |
| collection | DOAJ |
| description |
Introduction
Nowadays, the rates of antidepressant prescription are high and increasing. In this context, the issue of whether these medications are addictive has been increasingly discussed.
Objectives
The aim of this review was to explore the debate about the addictive property of antidepressants.
Methods
We conducted a literature review in the Pubmed database, using the search terms “antidepressants”, “SSRI”, “tricyclic”, “addiction”, “dependence” in various combinations, and narrowing the search to the last 10 years, to identify articles about the addiction to antidepressants.
Results
All the articles included in our study highlighted the fact that antidepressants were associated with withdrawal symptoms. These symptoms are heterogeneous, and long-lasting in some cases, and Paroxetine was shown to have particularly high rates of withdrawal symptoms.
Some articles reported a psychological and physical dependence on antidepressants. However, the most recent studies agreed that, using established classification systems and concepts and after integrating neurobiological and behavioral criteria, antidepressants are shown to have no addictive property.
Conclusions
Antidepressants are proven to be associated with withdrawal symptoms. Whether or not these symptoms are enough to constitute an “addiction” remains controversial, as recent studies agree that antidepressants should not be classified as addictive substances.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:52:13Z |
| format | Article |
| id | doaj.art-1309fe100fb14ce1a87326a104df1944 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:52:13Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-1309fe100fb14ce1a87326a104df19442023-11-17T05:06:26ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S671S67110.1192/j.eurpsy.2023.1399Are antidepressants addictive? a literature reviewM. Turki0O. Elleuch1F. Sahnoun2H. E. Mhiri3A. Guermazi4S. Ellouze5N. Halouani6J. Aloulou7Psychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, TunisiaPsychiatry B, Hedi Chaker University Hospital of Sfax, Sfax, Tunisia Introduction Nowadays, the rates of antidepressant prescription are high and increasing. In this context, the issue of whether these medications are addictive has been increasingly discussed. Objectives The aim of this review was to explore the debate about the addictive property of antidepressants. Methods We conducted a literature review in the Pubmed database, using the search terms “antidepressants”, “SSRI”, “tricyclic”, “addiction”, “dependence” in various combinations, and narrowing the search to the last 10 years, to identify articles about the addiction to antidepressants. Results All the articles included in our study highlighted the fact that antidepressants were associated with withdrawal symptoms. These symptoms are heterogeneous, and long-lasting in some cases, and Paroxetine was shown to have particularly high rates of withdrawal symptoms. Some articles reported a psychological and physical dependence on antidepressants. However, the most recent studies agreed that, using established classification systems and concepts and after integrating neurobiological and behavioral criteria, antidepressants are shown to have no addictive property. Conclusions Antidepressants are proven to be associated with withdrawal symptoms. Whether or not these symptoms are enough to constitute an “addiction” remains controversial, as recent studies agree that antidepressants should not be classified as addictive substances. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823013998/type/journal_article |
| spellingShingle | M. Turki O. Elleuch F. Sahnoun H. E. Mhiri A. Guermazi S. Ellouze N. Halouani J. Aloulou Are antidepressants addictive? a literature review European Psychiatry |
| title | Are antidepressants addictive? a literature review |
| title_full | Are antidepressants addictive? a literature review |
| title_fullStr | Are antidepressants addictive? a literature review |
| title_full_unstemmed | Are antidepressants addictive? a literature review |
| title_short | Are antidepressants addictive? a literature review |
| title_sort | are antidepressants addictive a literature review |
| url | https://www.cambridge.org/core/product/identifier/S0924933823013998/type/journal_article |
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