Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity
Large cell neuroendocrine carcinoma (LCNEC) is a rare but distinct entity of nasal cavity carcinomas. Only a very few cases have been reported in the nasal cavity. Its treatment is not well established. We report the case of a LCNEC in a 70 years old patient who presented with right nasal obstructio...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2018-06-01
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| Series: | The Pan African Medical Journal |
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| Online Access: |
https://www.panafrican-med-journal.com/content/article/30/188/pdf/188.pdf
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| author | Jawad Lahma Reda Hejjouji Philippe Gicquel Leila Essakalli |
| author_facet | Jawad Lahma Reda Hejjouji Philippe Gicquel Leila Essakalli |
| author_sort | Jawad Lahma |
| collection | DOAJ |
| description | Large cell neuroendocrine carcinoma (LCNEC) is a rare but distinct entity of nasal cavity carcinomas. Only a very few cases have been reported in the nasal cavity. Its treatment is not well established. We report the case of a LCNEC in a 70 years old patient who presented with right nasal obstruction and epistaxis since 2 months. Diagnosis was confirmed by histological and immunohistochemical study. The patient underwent complete endoscopic removal of the tumor combined to adjuvant chemoradiotherapy. After 6 month follow-up, the patient was in complete clinical and radiological remission. We will discuss in this paper the various epidemiology, clinical features, pathological findings, differential diagnosis, and evolution of treatment of this uncommon malignancy in the light of current knowledge. Optimal treatment strategies are yet to be determined for this rare malignancy with poor prognosis including surgery and chemoradiotherapy. |
| first_indexed | 2024-12-20T22:58:24Z |
| format | Article |
| id | doaj.art-130a1a0aa7e34e9a837714a0a8f6a64e |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T22:58:24Z |
| publishDate | 2018-06-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-130a1a0aa7e34e9a837714a0a8f6a64e2022-12-21T19:24:03ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882018-06-013018810.11604/pamj.2018.30.188.1499214992Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entityJawad Lahma0Reda Hejjouji1Philippe Gicquel2Leila Essakalli3 ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco ENT Department, Hospital Center of Niort, France ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco Large cell neuroendocrine carcinoma (LCNEC) is a rare but distinct entity of nasal cavity carcinomas. Only a very few cases have been reported in the nasal cavity. Its treatment is not well established. We report the case of a LCNEC in a 70 years old patient who presented with right nasal obstruction and epistaxis since 2 months. Diagnosis was confirmed by histological and immunohistochemical study. The patient underwent complete endoscopic removal of the tumor combined to adjuvant chemoradiotherapy. After 6 month follow-up, the patient was in complete clinical and radiological remission. We will discuss in this paper the various epidemiology, clinical features, pathological findings, differential diagnosis, and evolution of treatment of this uncommon malignancy in the light of current knowledge. Optimal treatment strategies are yet to be determined for this rare malignancy with poor prognosis including surgery and chemoradiotherapy. https://www.panafrican-med-journal.com/content/article/30/188/pdf/188.pdf large cell neuroendocrine carcinomanasal cavityendoscopic endonasal surgery |
| spellingShingle | Jawad Lahma Reda Hejjouji Philippe Gicquel Leila Essakalli Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity The Pan African Medical Journal large cell neuroendocrine carcinoma nasal cavity endoscopic endonasal surgery |
| title | Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity |
| title_full | Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity |
| title_fullStr | Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity |
| title_full_unstemmed | Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity |
| title_short | Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity |
| title_sort | large cell neuroendocrine carcinoma of the nasal cavity an extremely rare and new distinct entity |
| topic | large cell neuroendocrine carcinoma nasal cavity endoscopic endonasal surgery |
| url |
https://www.panafrican-med-journal.com/content/article/30/188/pdf/188.pdf
|
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