Sarcoma metastasis to the pancreas: experience at a single institution
Background Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases. Methods We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017. Results Metastatic tumors to the pancreas...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2020-05-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2020-03-04.pdf |
| _version_ | 1828443053134708736 |
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| author | Miseon Lee Joon Seon Song Seung-Mo Hong Se Jin Jang Jihun Kim Ki Byung Song Jae Hoon Lee Kyung-Ja Cho |
| author_facet | Miseon Lee Joon Seon Song Seung-Mo Hong Se Jin Jang Jihun Kim Ki Byung Song Jae Hoon Lee Kyung-Ja Cho |
| author_sort | Miseon Lee |
| collection | DOAJ |
| description | Background Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases. Methods We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017. Results Metastatic tumors to the pancreas consisted of 111 carcinomas (89.5%), 12 sarcomas (9.6%), and one melanoma (0.8%). Primary sarcoma sites were bone (n=4); brain, lung, and soft tissue (n=2 for each); and the uterus and pulmonary vein (n=1 for each). Pathologically, the 12 sarcomas comprised 2 World Health Organization grade III solitary fibrous tumors/hemangiopericytomas, and one case each of synovial sarcoma, malignant solitary fibrous tumor, undifferentiated pleomorphic sarcoma, osteosarcoma, mesenchymal chondrosarcoma, intimal sarcoma, myxofibrosarcoma, myxoid liposarcoma, rhabdomyosarcoma, subtype uncertain, and high-grade spindle-cell sarcoma of uncertain type. The median interval between primary cancer diagnosis and pancreatic metastasis was 28.5 months. One case manifested as a solitary pancreatic osteosarcoma metastasis 15 months prior to detection of osteosarcoma in the femur and was initially misdiagnosed as sarcomatoid carcinoma of the pancreas. Conclusions The metastatic sarcoma should remain a differential diagnosis when spindle-cell malignancy is found in the pancreas, even for solitary lesions or in patients without prior history. |
| first_indexed | 2024-12-10T21:23:33Z |
| format | Article |
| id | doaj.art-13146928676f4561b3c5f12e5e3c5812 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-10T21:23:33Z |
| publishDate | 2020-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-13146928676f4561b3c5f12e5e3c58122022-12-22T01:33:03ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452020-05-0154322022710.4132/jptm.2020.03.0416908Sarcoma metastasis to the pancreas: experience at a single institutionMiseon Lee0Joon Seon Song1Seung-Mo Hong2Se Jin Jang3Jihun Kim4Ki Byung Song5Jae Hoon Lee6Kyung-Ja Cho7 Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases. Methods We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017. Results Metastatic tumors to the pancreas consisted of 111 carcinomas (89.5%), 12 sarcomas (9.6%), and one melanoma (0.8%). Primary sarcoma sites were bone (n=4); brain, lung, and soft tissue (n=2 for each); and the uterus and pulmonary vein (n=1 for each). Pathologically, the 12 sarcomas comprised 2 World Health Organization grade III solitary fibrous tumors/hemangiopericytomas, and one case each of synovial sarcoma, malignant solitary fibrous tumor, undifferentiated pleomorphic sarcoma, osteosarcoma, mesenchymal chondrosarcoma, intimal sarcoma, myxofibrosarcoma, myxoid liposarcoma, rhabdomyosarcoma, subtype uncertain, and high-grade spindle-cell sarcoma of uncertain type. The median interval between primary cancer diagnosis and pancreatic metastasis was 28.5 months. One case manifested as a solitary pancreatic osteosarcoma metastasis 15 months prior to detection of osteosarcoma in the femur and was initially misdiagnosed as sarcomatoid carcinoma of the pancreas. Conclusions The metastatic sarcoma should remain a differential diagnosis when spindle-cell malignancy is found in the pancreas, even for solitary lesions or in patients without prior history.http://www.jpatholtm.org/upload/pdf/jptm-2020-03-04.pdfpancreasmetastasissarcoma |
| spellingShingle | Miseon Lee Joon Seon Song Seung-Mo Hong Se Jin Jang Jihun Kim Ki Byung Song Jae Hoon Lee Kyung-Ja Cho Sarcoma metastasis to the pancreas: experience at a single institution Journal of Pathology and Translational Medicine pancreas metastasis sarcoma |
| title | Sarcoma metastasis to the pancreas: experience at a single institution |
| title_full | Sarcoma metastasis to the pancreas: experience at a single institution |
| title_fullStr | Sarcoma metastasis to the pancreas: experience at a single institution |
| title_full_unstemmed | Sarcoma metastasis to the pancreas: experience at a single institution |
| title_short | Sarcoma metastasis to the pancreas: experience at a single institution |
| title_sort | sarcoma metastasis to the pancreas experience at a single institution |
| topic | pancreas metastasis sarcoma |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2020-03-04.pdf |
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