Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy
Abstract Introduction This study assessed the efficacy and safety of intense pulsed light (IPL) therapy in participants with severe evaporative dry eye disease (DED). Methods This randomized, controlled, single-center study included 49 adult participants (≥ 18 years) with severe evaporative DED who...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-01-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-023-00649-5 |
| _version_ | 1827984950934110208 |
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| author | Guanghao Qin Jiayan Chen Liangzhe Li Yang Xia Qing Zhang Yi Wu Lanting Yang Salissou Moutari Jonathan E. Moore Ling Xu Wei He Sile Yu Xingru He Emmanuel Eric Pazo |
| author_facet | Guanghao Qin Jiayan Chen Liangzhe Li Yang Xia Qing Zhang Yi Wu Lanting Yang Salissou Moutari Jonathan E. Moore Ling Xu Wei He Sile Yu Xingru He Emmanuel Eric Pazo |
| author_sort | Guanghao Qin |
| collection | DOAJ |
| description | Abstract Introduction This study assessed the efficacy and safety of intense pulsed light (IPL) therapy in participants with severe evaporative dry eye disease (DED). Methods This randomized, controlled, single-center study included 49 adult participants (≥ 18 years) with severe evaporative DED who received either IPL therapy (n = 56 eyes) or sham therapy (n = 42 eyes) three times. The primary efficacy parameters were ocular surface disease index (OSDI) score, non-invasive tear breakup time (NITBUT), tear film lipid layer (TFLL), conjunctivocorneal staining score (CS), MG Score, meibomian gland (MG) quality, and MG expression score. Results The mean ages for the IPL group and the control group were 28.05 ± 3.41 years (57.1% female) and 28.14 ± 3.53 years (52.4% female), respectively. Comparison between the IPL group and the control group found significant differences in the mean OSDI score (22.16 ± 6.08 vs. 42.38 ± 6.60; P < 00.01), NITBUT (6.27 ± 0.84 vs. 3.86 ± 0.68; P < 0.001), TFLL (2.14 ± 0.44 vs. 3.45 ± 0.50; P < 0.001), MG Score (1.34 ± 0.55 vs. 1.88 ± 0.33; P < 0.001), MG quality (1.59 ± 0.07 vs. 2.67 ± 0.08), and MG expression (1.54 ± 0.57 vs. 2.45 ± 0.55) at 12 weeks follow-up; however, there was no significant difference in CS (3.32 ± 1.11 vs. 3.74 ± 1.04; P = 0.063). Conclusion The findings suggest that IPL therapy is clinically beneficial in ameliorating the signs and symptoms of severe evaporative dry eye disease. |
| first_indexed | 2024-04-09T23:07:03Z |
| format | Article |
| id | doaj.art-1314f048d8914cc3a0ec990c20521f6d |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-04-09T23:07:03Z |
| publishDate | 2023-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-1314f048d8914cc3a0ec990c20521f6d2023-03-22T10:36:31ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-01-011221059107110.1007/s40123-023-00649-5Managing Severe Evaporative Dry Eye with Intense Pulsed Light TherapyGuanghao Qin0Jiayan Chen1Liangzhe Li2Yang Xia3Qing Zhang4Yi Wu5Lanting Yang6Salissou Moutari7Jonathan E. Moore8Ling Xu9Wei He10Sile Yu11Xingru He12Emmanuel Eric Pazo13Department of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalTianjin Medical Eye HospitalChina Medical UniversityWenzhou Medical UniversityQueens University BelfastCathedral Eye ClinicDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalDepartment of Ophthalmology, He Eye Specialist HospitalAbstract Introduction This study assessed the efficacy and safety of intense pulsed light (IPL) therapy in participants with severe evaporative dry eye disease (DED). Methods This randomized, controlled, single-center study included 49 adult participants (≥ 18 years) with severe evaporative DED who received either IPL therapy (n = 56 eyes) or sham therapy (n = 42 eyes) three times. The primary efficacy parameters were ocular surface disease index (OSDI) score, non-invasive tear breakup time (NITBUT), tear film lipid layer (TFLL), conjunctivocorneal staining score (CS), MG Score, meibomian gland (MG) quality, and MG expression score. Results The mean ages for the IPL group and the control group were 28.05 ± 3.41 years (57.1% female) and 28.14 ± 3.53 years (52.4% female), respectively. Comparison between the IPL group and the control group found significant differences in the mean OSDI score (22.16 ± 6.08 vs. 42.38 ± 6.60; P < 00.01), NITBUT (6.27 ± 0.84 vs. 3.86 ± 0.68; P < 0.001), TFLL (2.14 ± 0.44 vs. 3.45 ± 0.50; P < 0.001), MG Score (1.34 ± 0.55 vs. 1.88 ± 0.33; P < 0.001), MG quality (1.59 ± 0.07 vs. 2.67 ± 0.08), and MG expression (1.54 ± 0.57 vs. 2.45 ± 0.55) at 12 weeks follow-up; however, there was no significant difference in CS (3.32 ± 1.11 vs. 3.74 ± 1.04; P = 0.063). Conclusion The findings suggest that IPL therapy is clinically beneficial in ameliorating the signs and symptoms of severe evaporative dry eye disease.https://doi.org/10.1007/s40123-023-00649-5Dry eyeEvaporative dry eyeSevere dry eyeIntense pulsed light |
| spellingShingle | Guanghao Qin Jiayan Chen Liangzhe Li Yang Xia Qing Zhang Yi Wu Lanting Yang Salissou Moutari Jonathan E. Moore Ling Xu Wei He Sile Yu Xingru He Emmanuel Eric Pazo Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy Ophthalmology and Therapy Dry eye Evaporative dry eye Severe dry eye Intense pulsed light |
| title | Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy |
| title_full | Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy |
| title_fullStr | Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy |
| title_full_unstemmed | Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy |
| title_short | Managing Severe Evaporative Dry Eye with Intense Pulsed Light Therapy |
| title_sort | managing severe evaporative dry eye with intense pulsed light therapy |
| topic | Dry eye Evaporative dry eye Severe dry eye Intense pulsed light |
| url | https://doi.org/10.1007/s40123-023-00649-5 |
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