Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors

Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors

Objective(s): Nowadays, COX- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. In response to this, medicinal chemists have attempted to synthesize new classes of COX-2 Inhibitors.   Materials an...

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Main Authors: Seyed Adel Moallem, Mohsen Imenshahidi, Narges Shahini, Ahmad Reza Javan, Mohsen Karimi, Mona Alibolandi, Morteza Ghandadi, Leila Etemad, Vahidehsadat Motamedshariaty, Toktam Hosseini, Farzin Hadizadeh
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2013-12-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Antinociceptive Anti-Inflammatory Anticancer Celecoxib COX-2 inhibitor Thiazolidin-4-ones
Online Access:http://ijbms.mums.ac.ir/pdf_1982_8f308be02e1569af889ab444f6a46bc7.html

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