Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.

Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.

We have previously described a RAF oncogene driven transgenic mouse model for non small cell lung cancer (NSCLC). Here we examine whether tumor initiation and growth requires the stem cell self-renewal factor Bmi1.In order to evaluate Bmi1 function in NSCLC two founder lines that differ in incidence...

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Bibliographic Details
Main Authors: Matthias Becker, Christian Korn, Arnold R Sienerth, Robert Voswinckel, Katharina Luetkenhaus, Fatih Ceteci, Ulf R Rapp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2626631?pdf=render

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