Rats’ umbilical-cord mesenchymal stem cells ameliorate mast cells and Hsp70 on ovalbumin-induced allergic rhinitis rats
Aim Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immun...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical Association of Zenica-Doboj Canton
2022-02-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | https://ljkzedo.ba/mgpdf/mg36/09_Restimulia_1421_A.pdf |
| Summary: | Aim Allergic rhinitis (AR) is a heterogeneous condition that has
been associated with inflammatory responses and is characterized
by clinical typical symptoms of nasal itching, sneezing, watery
discharge and congestion. Mesenchymal stem cells (MSCs) are
multipotent stem cells that have the immunoregulatory ability by
secreting various cytokines which potent as a promising therapeutic modality for allergic airway diseases, including AR. The aim
of this study was to investigate the effect of rat UC-MSCs on the
number of mast cells, the expression of Hsp70 indicated by the
nasal symptoms allergic, particularly nasal rubbing in ovalbumininduced AR rats.
Methods Fifteen male Wistar rats (6 to 8 weeks old) were randomly divided into three groups (control group, sham group, and
OVA+MSCs group). OVA nasal challenge was conducted daily
from day 15 to 21, and UC-MSCs (1x106
) were administrated intraperitoneally to OVA-sensitized rats on day 21. Nasal rubbing
was observed from day 22 to 28. The rats were sacrificed on day
22 and day 28. The nasal cavity tissues were prepared for histological observations.
Results The administration of UC-MSCs could reduce the number
of mast cells and the expression of Hsp70 leading to reduction of
nasal symptoms allergic, particularly nasal rubbing.
Conclusion Based on this finding, MSCs present a promising
immediate curative effect to the inflammatory reaction in AR rats. |
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| ISSN: | 1840-0132 1840-2445 |