The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations]
Background: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice are likely. A living systematic review (LSR) can narrow this...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-07-01
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| Online Access: | https://f1000research.com/articles/10-235/v2 |
| _version_ | 1811309160674885632 |
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| author | Christian Apfelbacher Michael Perkin Jon Genuneit Helge Knüttel Jiancong Wang Christina Tischer Uwe Matterne |
| author_facet | Christian Apfelbacher Michael Perkin Jon Genuneit Helge Knüttel Jiancong Wang Christina Tischer Uwe Matterne |
| author_sort | Christian Apfelbacher |
| collection | DOAJ |
| description | Background: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice are likely. A living systematic review (LSR) can narrow this gap by incorporating new evidence as it becomes available. No efficacy comparisons across various ECAP interventions for similar outcomes have been carried out. Networks of randomised clinical trials can be evaluated in the context of a network meta-analysis (NMA). We aim to establish a LSR on the efficacy and safety of any intervention investigated in randomised controlled trials (RCT) to prevent the occurrence of allergic sensitisation (AS), symptoms or diagnoses of allergic diseases in infancy and early childhood (0-3 years). Methods: A baseline SR will synthesise the evidence from existing SRs of RCTs as well as RCTs not yet considered in these. After completion of the baseline SR we propose to conduct a LSR. Using this methodology, we aim to undertake constant evidence surveillance, three-monthly search updates, and review updates every three months, should new evidence emerge. Conclusions: The ECAP evidence landscape has undergone dramatic transformations and this process is likely to continue. As a response to this, a LSR offers the potential to allow more timely synthesis of new evidence as it emerges. Long gaps between updates of SRs makes it harder for guidelines and recommendations to be up to date. Users of information, such as parents, may be confused if they encounter new evidence that is not part of a trusted guideline. A LSR approach allows us to continuously search the literature and update the evidence-base of existing ECAP interventions resulting in a decreased timespan from evidence accrual to informing clinical practice. |
| first_indexed | 2024-04-13T09:36:17Z |
| format | Article |
| id | doaj.art-131fb3c2c69440e98eea40305768137d |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T09:36:17Z |
| publishDate | 2021-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-131fb3c2c69440e98eea40305768137d2022-12-22T02:52:04ZengF1000 Research LtdF1000Research2046-14022021-07-011058562The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations]Christian Apfelbacher0https://orcid.org/0000-0003-3805-8219Michael Perkin1https://orcid.org/0000-0001-9272-2585Jon Genuneit2Helge Knüttel3https://orcid.org/0000-0002-2654-6517Jiancong Wang4https://orcid.org/0000-0001-6284-9702Christina Tischer5Uwe Matterne6https://orcid.org/0000-0003-4935-1904Institute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, GermanyPopulation Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UKPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Liebigstraße 20a, Leipzig, 04103, GermanyUniversity Library, University of Regensburg, Universitätsstraße 31, Regensburg, 93053, GermanyInstitute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, GermanyInstitute for Health Resort Medicine and Health Promotion, State Institute of Health, Bavarian Health and Food Safety Authority, Prinzregentenstraße 6, Bad Kissingen, 97688, GermanyInstitute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, GermanyBackground: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice are likely. A living systematic review (LSR) can narrow this gap by incorporating new evidence as it becomes available. No efficacy comparisons across various ECAP interventions for similar outcomes have been carried out. Networks of randomised clinical trials can be evaluated in the context of a network meta-analysis (NMA). We aim to establish a LSR on the efficacy and safety of any intervention investigated in randomised controlled trials (RCT) to prevent the occurrence of allergic sensitisation (AS), symptoms or diagnoses of allergic diseases in infancy and early childhood (0-3 years). Methods: A baseline SR will synthesise the evidence from existing SRs of RCTs as well as RCTs not yet considered in these. After completion of the baseline SR we propose to conduct a LSR. Using this methodology, we aim to undertake constant evidence surveillance, three-monthly search updates, and review updates every three months, should new evidence emerge. Conclusions: The ECAP evidence landscape has undergone dramatic transformations and this process is likely to continue. As a response to this, a LSR offers the potential to allow more timely synthesis of new evidence as it emerges. Long gaps between updates of SRs makes it harder for guidelines and recommendations to be up to date. Users of information, such as parents, may be confused if they encounter new evidence that is not part of a trusted guideline. A LSR approach allows us to continuously search the literature and update the evidence-base of existing ECAP interventions resulting in a decreased timespan from evidence accrual to informing clinical practice.https://f1000research.com/articles/10-235/v2Early childhood allergy prevention randomised controlled trial living systematic revieweng |
| spellingShingle | Christian Apfelbacher Michael Perkin Jon Genuneit Helge Knüttel Jiancong Wang Christina Tischer Uwe Matterne The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research Early childhood allergy prevention randomised controlled trial living systematic review eng |
| title | The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | evidence for interventions in early childhood allergy prevention towards a living systematic review protocol version 2 peer review 1 approved 2 approved with reservations |
| topic | Early childhood allergy prevention randomised controlled trial living systematic review eng |
| url | https://f1000research.com/articles/10-235/v2 |
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