ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs
The full potential of single-cell RNA-sequencing applied to precision medicine has yet to be reached. Here, we propose a drug recommendation system ASGARD, which predicts drugs by considering cell clusters to address the intercellular heterogeneity within each patient.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36637-3 |
| _version_ | 1797864197035393024 |
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| author | Bing He Yao Xiao Haodong Liang Qianhui Huang Yuheng Du Yijun Li David Garmire Duxin Sun Lana X. Garmire |
| author_facet | Bing He Yao Xiao Haodong Liang Qianhui Huang Yuheng Du Yijun Li David Garmire Duxin Sun Lana X. Garmire |
| author_sort | Bing He |
| collection | DOAJ |
| description | The full potential of single-cell RNA-sequencing applied to precision medicine has yet to be reached. Here, we propose a drug recommendation system ASGARD, which predicts drugs by considering cell clusters to address the intercellular heterogeneity within each patient. |
| first_indexed | 2024-04-09T22:49:00Z |
| format | Article |
| id | doaj.art-131fd617bdab4078a2b92ebece138f5a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:00Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-131fd617bdab4078a2b92ebece138f5a2023-03-22T11:42:29ZengNature PortfolioNature Communications2041-17232023-02-0114111410.1038/s41467-023-36637-3ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of DrugsBing He0Yao Xiao1Haodong Liang2Qianhui Huang3Yuheng Du4Yijun Li5David Garmire6Duxin Sun7Lana X. Garmire8Department of Computational Medicine and Bioinformatics, Medical School, University of MichiganDepartment of Computational Medicine and Bioinformatics, Medical School, University of MichiganDepartment of Statistics, College of Literature, Science, and the Arts, University of MichiganDepartment of Computational Medicine and Bioinformatics, Medical School, University of MichiganDepartment of Computational Medicine and Bioinformatics, Medical School, University of MichiganDepartment of Computational Medicine and Bioinformatics, Medical School, University of MichiganDepartment of Electrical Engineering and Computer Science, College of Engineering, University of MichiganDepartment of Pharmaceutical Sciences, College of Pharmacy, University of MichiganDepartment of Computational Medicine and Bioinformatics, Medical School, University of MichiganThe full potential of single-cell RNA-sequencing applied to precision medicine has yet to be reached. Here, we propose a drug recommendation system ASGARD, which predicts drugs by considering cell clusters to address the intercellular heterogeneity within each patient.https://doi.org/10.1038/s41467-023-36637-3 |
| spellingShingle | Bing He Yao Xiao Haodong Liang Qianhui Huang Yuheng Du Yijun Li David Garmire Duxin Sun Lana X. Garmire ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs Nature Communications |
| title | ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs |
| title_full | ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs |
| title_fullStr | ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs |
| title_full_unstemmed | ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs |
| title_short | ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs |
| title_sort | asgard is a single cell guided pipeline to aid repurposing of drugs |
| url | https://doi.org/10.1038/s41467-023-36637-3 |
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