Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy
The canine mammary tumor is the neoplasia that most commonly affects intact female dogs (not spayed) in routine veterinary practice. Canine mammary tumor therapy is a challenge because only few effective treatments have been described for high-grade tumors in veterinary medicine. One such therapeuti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Londrina
2019-07-01
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| Series: | Semina: Ciências Agrárias |
| Subjects: | |
| Online Access: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/33018 |
| _version_ | 1797944253388685312 |
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| author | Analy Ramos Mendes Ferrari Heitor Flavio Ferrari Vinicius Soares Carreira Edenilson Doná Frigério Maria Cecília Rui Luvizotto Alexandre Lima de Andrade |
| author_facet | Analy Ramos Mendes Ferrari Heitor Flavio Ferrari Vinicius Soares Carreira Edenilson Doná Frigério Maria Cecília Rui Luvizotto Alexandre Lima de Andrade |
| author_sort | Analy Ramos Mendes Ferrari |
| collection | DOAJ |
| description | The canine mammary tumor is the neoplasia that most commonly affects intact female dogs (not spayed) in routine veterinary practice. Canine mammary tumor therapy is a challenge because only few effective treatments have been described for high-grade tumors in veterinary medicine. One such therapeutic option that slows down tumor growth is metronomic chemotherapy (MC), a therapeutic modality that acts by decreasing tumor angiogenesis. Quantification of intratumoral microvessel density (MVD) has been proposed as a means to evaluate the effectiveness of MC in human and canine tumors. In this study, MVD is proposed as a predictive factor for the effectiveness of MC in canine mammary tumors. Twenty female dogs with mammary carcinoma were equally distributed into a mastectomy group treated only with mastectomy, and a MC group treated with MC (cyclophosphamide and piroxicam) orally and daily for 28 days followed by mastectomy. Mammary tumors were classified and graded histologically. MVD was ascertained by CD31 immunostaining. The analysis showed statistically significant difference in MVD scores between groups, corroborating a quantitative reduction in tumor microvasculature in the group treated with MC. Our findings suggest that MVD may be an important predictive factor for the selection of female dogs with malignant mammary tumors that may benefit from MC. |
| first_indexed | 2024-04-10T20:36:47Z |
| format | Article |
| id | doaj.art-132150ac90734577ac86bc6003cb8a99 |
| institution | Directory Open Access Journal |
| issn | 1676-546X 1679-0359 |
| language | English |
| last_indexed | 2024-04-10T20:36:47Z |
| publishDate | 2019-07-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Agrárias |
| spelling | doaj.art-132150ac90734577ac86bc6003cb8a992023-01-24T20:31:17ZengUniversidade Estadual de LondrinaSemina: Ciências Agrárias1676-546X1679-03592019-07-0140510.5433/1679-0359.2019v40n5p1849Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapyAnaly Ramos Mendes Ferrari0Heitor Flavio Ferrari1Vinicius Soares Carreira2Edenilson Doná Frigério3Maria Cecília Rui Luvizotto4Alexandre Lima de Andrade5Universidade Estadual PaulistaCentro Universitário de AdamantinaVet Path ServicesUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaThe canine mammary tumor is the neoplasia that most commonly affects intact female dogs (not spayed) in routine veterinary practice. Canine mammary tumor therapy is a challenge because only few effective treatments have been described for high-grade tumors in veterinary medicine. One such therapeutic option that slows down tumor growth is metronomic chemotherapy (MC), a therapeutic modality that acts by decreasing tumor angiogenesis. Quantification of intratumoral microvessel density (MVD) has been proposed as a means to evaluate the effectiveness of MC in human and canine tumors. In this study, MVD is proposed as a predictive factor for the effectiveness of MC in canine mammary tumors. Twenty female dogs with mammary carcinoma were equally distributed into a mastectomy group treated only with mastectomy, and a MC group treated with MC (cyclophosphamide and piroxicam) orally and daily for 28 days followed by mastectomy. Mammary tumors were classified and graded histologically. MVD was ascertained by CD31 immunostaining. The analysis showed statistically significant difference in MVD scores between groups, corroborating a quantitative reduction in tumor microvasculature in the group treated with MC. Our findings suggest that MVD may be an important predictive factor for the selection of female dogs with malignant mammary tumors that may benefit from MC.https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/33018AngiogenesisAntiangiogenic chemotherapyFemale dogMammary tumor. |
| spellingShingle | Analy Ramos Mendes Ferrari Heitor Flavio Ferrari Vinicius Soares Carreira Edenilson Doná Frigério Maria Cecília Rui Luvizotto Alexandre Lima de Andrade Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy Semina: Ciências Agrárias Angiogenesis Antiangiogenic chemotherapy Female dog Mammary tumor. |
| title | Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| title_full | Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| title_fullStr | Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| title_full_unstemmed | Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| title_short | Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| title_sort | microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy |
| topic | Angiogenesis Antiangiogenic chemotherapy Female dog Mammary tumor. |
| url | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/33018 |
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