Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen. The LACV Gc glycoprotein plays a critical role in the neuropathogenesis of LACV encephalitis as the putative virus a...

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Bibliographic Details
Main Authors: Bradley S. Hollidge, Mary-Virginia Salzano, John M. Ibrahim, Jonathan W. Fraser, Valentina Wagner, Nicole E. Leitner, Susan R. Weiss, Friedemann Weber, Francisco González-Scarano, Samantha S. Soldan
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
La Crosse virus
fusion peptide
viral encephalitis
neuroinvasion
orthobunyavirus
<i>Bunyavirales</i>
Online Access:https://www.mdpi.com/1999-4915/14/7/1464

Internet

https://www.mdpi.com/1999-4915/14/7/1464

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