In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

Many studies of tauopathy use transgenic mice that overexpress the P301S mutant form of tau. Neuronal damage in these mice is associated with astrogliosis and induction of glial fibrillary acidic protein (GFAP) expression. GFAP-luc transgenic mice express firefly luciferase under the GFAP promoter,...

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Bibliographic Details
Main Authors: Ambrose A. Dunn-Meynell, Peter Dowling, Michelle Marchese, Esther Rodriguez, Benjamin Blumberg, Yun-Beom Choi, Deeya Gaindh, Wei Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
gliosis
glial fibrillary acidic protein
transgenic
PS19
erythropoietin
P301S
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00252/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00252/full

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