Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery
<p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) is a well-established risk factor for perioperative cardiovascular morbidity and mortality in patients undergoing noncardiac surgery. However, the impact of preoperative glucose levels on perioperative cardiova...
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| Format: | Article |
| Language: | English |
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BMC
2011-07-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://www.cardiab.com/content/10/1/63 |
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| author | Tekkeşin Ahmet Biteker Funda S İlhan Erkan Can Mehmet M Dayan Akin Biteker Murat Duman Dursun |
| author_facet | Tekkeşin Ahmet Biteker Funda S İlhan Erkan Can Mehmet M Dayan Akin Biteker Murat Duman Dursun |
| author_sort | Tekkeşin Ahmet |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) is a well-established risk factor for perioperative cardiovascular morbidity and mortality in patients undergoing noncardiac surgery. However, the impact of preoperative glucose levels on perioperative cardiovascular outcomes in patients undergoing nonemergent, major noncardiothoracic surgery is unclear.</p> <p>Methods and Results</p> <p>A total of 680 patients undergoing noncardiothoracic surgery were prospectively evaluated. Patients older than 18 years who underwent an elective, nonday case, open surgical procedure were enrolled. Electrocardiography and cardiac biomarkers were obtained 1 day before surgery, and on days 1, 3 and 7 after surgery. Preoperative risk factors and laboratory test results were measured and evaluated for their association with the occurrence of in-hospital perioperative cardiovascular events. Impaired fasting glucose (IFG) defined as fasting plasma glucose values of 100 to 125 mg/dl; DM was defined as fasting plasma glucose ≥ 126 mg/dl and/or plasma glucose ≥ 200 mg/dl or the current use of blood glucose-lowering medication, and glucose values below 100 mg/dl were considered normal. Plasma glucose levels were significantly higher in patients with perioperative cardiovascular events (n = 80, 11.8%) in comparison to those without cardiovascular events (131 ± 42.5 <it>vs </it>106.5 ± 37.5, p < 0.0001). Multivariate analysis revealed that patients with IFG and DM were at 2.1- and 6.4-fold increased risk of perioperative cardiovascular events, respectively. Every 10 mg/dl increase in preoperative plasma glucose levels was related to a 11% increase for adverse perioperative cardiovascular events.</p> <p>Conclusions</p> <p>Not only DM but also IFG is associated with increased perioperative cardiovascular event rates in patients undergoing noncardiothoracic surgery.</p> |
| first_indexed | 2024-12-13T21:04:22Z |
| format | Article |
| id | doaj.art-1325adce005d42648254985db0498d42 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-13T21:04:22Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-1325adce005d42648254985db0498d422022-12-21T23:31:30ZengBMCCardiovascular Diabetology1475-28402011-07-011016310.1186/1475-2840-10-63Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgeryTekkeşin AhmetBiteker Funda Sİlhan ErkanCan Mehmet MDayan AkinBiteker MuratDuman Dursun<p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) is a well-established risk factor for perioperative cardiovascular morbidity and mortality in patients undergoing noncardiac surgery. However, the impact of preoperative glucose levels on perioperative cardiovascular outcomes in patients undergoing nonemergent, major noncardiothoracic surgery is unclear.</p> <p>Methods and Results</p> <p>A total of 680 patients undergoing noncardiothoracic surgery were prospectively evaluated. Patients older than 18 years who underwent an elective, nonday case, open surgical procedure were enrolled. Electrocardiography and cardiac biomarkers were obtained 1 day before surgery, and on days 1, 3 and 7 after surgery. Preoperative risk factors and laboratory test results were measured and evaluated for their association with the occurrence of in-hospital perioperative cardiovascular events. Impaired fasting glucose (IFG) defined as fasting plasma glucose values of 100 to 125 mg/dl; DM was defined as fasting plasma glucose ≥ 126 mg/dl and/or plasma glucose ≥ 200 mg/dl or the current use of blood glucose-lowering medication, and glucose values below 100 mg/dl were considered normal. Plasma glucose levels were significantly higher in patients with perioperative cardiovascular events (n = 80, 11.8%) in comparison to those without cardiovascular events (131 ± 42.5 <it>vs </it>106.5 ± 37.5, p < 0.0001). Multivariate analysis revealed that patients with IFG and DM were at 2.1- and 6.4-fold increased risk of perioperative cardiovascular events, respectively. Every 10 mg/dl increase in preoperative plasma glucose levels was related to a 11% increase for adverse perioperative cardiovascular events.</p> <p>Conclusions</p> <p>Not only DM but also IFG is associated with increased perioperative cardiovascular event rates in patients undergoing noncardiothoracic surgery.</p>http://www.cardiab.com/content/10/1/63noncardiothoracic surgerypreoperative glucose levelscardiovascular complications |
| spellingShingle | Tekkeşin Ahmet Biteker Funda S İlhan Erkan Can Mehmet M Dayan Akin Biteker Murat Duman Dursun Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery Cardiovascular Diabetology noncardiothoracic surgery preoperative glucose levels cardiovascular complications |
| title | Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery |
| title_full | Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery |
| title_fullStr | Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery |
| title_full_unstemmed | Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery |
| title_short | Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery |
| title_sort | impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non cardiothoracic surgery |
| topic | noncardiothoracic surgery preoperative glucose levels cardiovascular complications |
| url | http://www.cardiab.com/content/10/1/63 |
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