A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy
Neurofibromatosis type 1 (NF1) is an inherited neurological disorder. Approximately 5–13% of NF1 patients may develop a malignant peripheral nerve sheath tumor (MPNST), which is a neurofibrosarcoma transformed from the plexiform neurofibroma or schwannoma. Given the large size and easy metastasis of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/4/317 |
| _version_ | 1797571643916156928 |
|---|---|
| author | Chin-Tin Chen Po-Chun Peng Tsuimin Tsai Hsiung-Fei Chien Ming-Jen Lee |
| author_facet | Chin-Tin Chen Po-Chun Peng Tsuimin Tsai Hsiung-Fei Chien Ming-Jen Lee |
| author_sort | Chin-Tin Chen |
| collection | DOAJ |
| description | Neurofibromatosis type 1 (NF1) is an inherited neurological disorder. Approximately 5–13% of NF1 patients may develop a malignant peripheral nerve sheath tumor (MPNST), which is a neurofibrosarcoma transformed from the plexiform neurofibroma or schwannoma. Given the large size and easy metastasis of MPNST, it remains difficult to be cured by either surgical or conventional chemotherapy. In this study, we investigated the possibility of combining photodynamic therapy (PDT) and chemotherapy to treat MPNST by using a dual-effect liposome (named as PL-cDDP-Ce6), in which a chemotherapeutic agent, cisplatin (cDDP), and photosensitizer, chlorine e6 (Ce6) were encapsulated in the same carrier. The cytotoxic effect of PL-cDDP-Ce6 against MPNST cells was significantly higher than cells treated with liposomal cDDP or Ce6 alone or in combination after light irradiation. Treatment with the dual-effect liposomes in mice bearing xenograft MPNST tumor reveals a significant increase in survival rate compared to those treated with liposomal cDDP and Ce6 in combination. Moreover, there is no weight loss or derangements of serum biochemistry. In conclusion, this study demonstrates the clinical potential and advantage of using this liposomal drug for the treatment of MPNST. |
| first_indexed | 2024-03-10T20:43:34Z |
| format | Article |
| id | doaj.art-1325de8dbea04e098fc6ce94f437e2fa |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:43:34Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1325de8dbea04e098fc6ce94f437e2fa2023-11-19T20:29:02ZengMDPI AGPharmaceutics1999-49232020-04-0112431710.3390/pharmaceutics12040317A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and ChemotherapyChin-Tin Chen0Po-Chun Peng1Tsuimin Tsai2Hsiung-Fei Chien3Ming-Jen Lee4Department of Biochemical Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, TaiwanDepartment of Biochemical Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, TaiwanGraduate Institute of Biomedical Materials and Engineering, Graduate School of Dentistry, Taipei Medical University, Taipei 11043, TaiwanDivision of Plastic Surgery, Department of Surgery, Taipei Medical University Hospital and College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Neurology, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei 10012, TaiwanNeurofibromatosis type 1 (NF1) is an inherited neurological disorder. Approximately 5–13% of NF1 patients may develop a malignant peripheral nerve sheath tumor (MPNST), which is a neurofibrosarcoma transformed from the plexiform neurofibroma or schwannoma. Given the large size and easy metastasis of MPNST, it remains difficult to be cured by either surgical or conventional chemotherapy. In this study, we investigated the possibility of combining photodynamic therapy (PDT) and chemotherapy to treat MPNST by using a dual-effect liposome (named as PL-cDDP-Ce6), in which a chemotherapeutic agent, cisplatin (cDDP), and photosensitizer, chlorine e6 (Ce6) were encapsulated in the same carrier. The cytotoxic effect of PL-cDDP-Ce6 against MPNST cells was significantly higher than cells treated with liposomal cDDP or Ce6 alone or in combination after light irradiation. Treatment with the dual-effect liposomes in mice bearing xenograft MPNST tumor reveals a significant increase in survival rate compared to those treated with liposomal cDDP and Ce6 in combination. Moreover, there is no weight loss or derangements of serum biochemistry. In conclusion, this study demonstrates the clinical potential and advantage of using this liposomal drug for the treatment of MPNST.https://www.mdpi.com/1999-4923/12/4/317NF1plexiform neurofibromaMPNSTchemotherapyliposome |
| spellingShingle | Chin-Tin Chen Po-Chun Peng Tsuimin Tsai Hsiung-Fei Chien Ming-Jen Lee A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy Pharmaceutics NF1 plexiform neurofibroma MPNST chemotherapy liposome |
| title | A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy |
| title_full | A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy |
| title_fullStr | A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy |
| title_full_unstemmed | A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy |
| title_short | A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy |
| title_sort | novel treatment modality for malignant peripheral nerve sheath tumor using a dual effect liposome to combine photodynamic therapy and chemotherapy |
| topic | NF1 plexiform neurofibroma MPNST chemotherapy liposome |
| url | https://www.mdpi.com/1999-4923/12/4/317 |
| work_keys_str_mv | AT chintinchen anoveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT pochunpeng anoveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT tsuimintsai anoveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT hsiungfeichien anoveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT mingjenlee anoveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT chintinchen noveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT pochunpeng noveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT tsuimintsai noveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT hsiungfeichien noveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy AT mingjenlee noveltreatmentmodalityformalignantperipheralnervesheathtumorusingadualeffectliposometocombinephotodynamictherapyandchemotherapy |