Propagation of Pathological α-Synuclein from the Urogenital Tract to the Brain Initiates MSA-like Syndrome

Propagation of Pathological α-Synuclein from the Urogenital Tract to the Brain Initiates MSA-like Syndrome

Summary: The neuropathological feature of multiple system atrophy (MSA), a fatal adult-onset disorder without effective therapy, is the accumulation of pathological α-synuclein (α-Syn) in the central nervous system (CNS). Here we show that pathological α-Syn exists in nerve terminals in detrusor and...

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Bibliographic Details
Main Authors: Xuebing Ding, Lebo Zhou, Xiaoyi Jiang, Han Liu, Jing Yao, Rui Zhang, Dongxiao Liang, Fengfei Wang, Mingming Ma, Beisha Tang, Erxi Wu, Junfang Teng, Xuejing Wang
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Biological Sciences
Neuroscience
Behavioral Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303515

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http://www.sciencedirect.com/science/article/pii/S2589004220303515

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