Retinal Pigment Epithelium Transplantation: Past, Present, and Future
Abstract Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2022-11-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v17i4.12325 |
| _version_ | 1811177661920182272 |
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| author | Ayyad Zartasht Khan Tor Paaske Utheim Jon Roger Eidet |
| author_facet | Ayyad Zartasht Khan Tor Paaske Utheim Jon Roger Eidet |
| author_sort | Ayyad Zartasht Khan |
| collection | DOAJ |
| description | Abstract Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized in vivo, sustainable in vitro, anddifferentiated from stem cells with a relatively straightforward protocol. Due to these properties and the clinical significance of this epithelium in various retinal diseases, RPE transplantation as a treatment modality has gained considerable interest in the last decade. This paper presents the main techniques for RPE transplantation and discusses recent clinically relevant publications. |
| first_indexed | 2024-04-11T06:06:01Z |
| format | Article |
| id | doaj.art-132653abaa8f405eb438baa26f73850c |
| institution | Directory Open Access Journal |
| issn | 2008-2010 2008-322X |
| language | English |
| last_indexed | 2024-04-11T06:06:01Z |
| publishDate | 2022-11-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-132653abaa8f405eb438baa26f73850c2022-12-22T04:41:30ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2022-11-0117457458010.18502/jovr.v17i4.12325jovr.v17i4.12325Retinal Pigment Epithelium Transplantation: Past, Present, and FutureAyyad Zartasht Khan0Tor Paaske Utheim1Jon Roger Eidet2 Department of Medical Biochemistry, Oslo University Hospital, Kirkeveien 166, Nydalen, Oslo, Norway Department of Oral Biology, Faculty of Dentistry, University of Oslo, Sognsvannsveien 10, Oslo, Norway Department of Ophthalmology, Oslo University Hospital, Kirkeveien 166, Nydalen, Oslo, NorwayAbstract Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized in vivo, sustainable in vitro, anddifferentiated from stem cells with a relatively straightforward protocol. Due to these properties and the clinical significance of this epithelium in various retinal diseases, RPE transplantation as a treatment modality has gained considerable interest in the last decade. This paper presents the main techniques for RPE transplantation and discusses recent clinically relevant publications.https://doi.org/10.18502/jovr.v17i4.12325retinal pigment epitheliumretinal pigment epithelium transplantationregenerative medicinevitreoretinal surgerytissue engineering. |
| spellingShingle | Ayyad Zartasht Khan Tor Paaske Utheim Jon Roger Eidet Retinal Pigment Epithelium Transplantation: Past, Present, and Future Journal of Ophthalmic & Vision Research retinal pigment epithelium retinal pigment epithelium transplantation regenerative medicine vitreoretinal surgery tissue engineering. |
| title | Retinal Pigment Epithelium Transplantation: Past, Present, and Future |
| title_full | Retinal Pigment Epithelium Transplantation: Past, Present, and Future |
| title_fullStr | Retinal Pigment Epithelium Transplantation: Past, Present, and Future |
| title_full_unstemmed | Retinal Pigment Epithelium Transplantation: Past, Present, and Future |
| title_short | Retinal Pigment Epithelium Transplantation: Past, Present, and Future |
| title_sort | retinal pigment epithelium transplantation past present and future |
| topic | retinal pigment epithelium retinal pigment epithelium transplantation regenerative medicine vitreoretinal surgery tissue engineering. |
| url | https://doi.org/10.18502/jovr.v17i4.12325 |
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