Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women
The increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metab...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/1/73 |
| _version_ | 1797492004842635264 |
|---|---|
| author | Renata Vargas Sinatora Eduardo Federighi Baisi Chagas Fernando Otavio Pires Mattera Luciano Junqueira Mellem Ana Rita de Oliveira dos Santos Larissa Pires Pereira Ana Luíza de Carvalho Aranão Elen Landgraf Guiguer Adriano Cressoni Araújo Jesselina F. dos Santos Haber Leila Campos Guissoni Sandra Maria Barbalho |
| author_facet | Renata Vargas Sinatora Eduardo Federighi Baisi Chagas Fernando Otavio Pires Mattera Luciano Junqueira Mellem Ana Rita de Oliveira dos Santos Larissa Pires Pereira Ana Luíza de Carvalho Aranão Elen Landgraf Guiguer Adriano Cressoni Araújo Jesselina F. dos Santos Haber Leila Campos Guissoni Sandra Maria Barbalho |
| author_sort | Renata Vargas Sinatora |
| collection | DOAJ |
| description | The increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metabolic syndrome (MS) in postmenopausal women considering different diagnostic criteria. We conducted a cross-sectional observational study based on STROBE. Data were collected regarding the diagnostic criteria for MS (International Diabetes Federation; NCEP (International Diabetes Federation (IDF), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and Harmonized criteria), body composition, comorbidities, time without menstruation, values of IL-6, IL-10, and TNF-α. ANOVA, Kruskal–Wallis, Levene tests, ROC, and odds ratio were performed to analyze the data. The results showed no significant difference between the methods and no interaction between the method and the presence of MS. However, for the values of WC, body fat percentage, TNF-α, and IL-10/TNF-α ratio, a significant effect of MS was observed. In subjects with MS, lower values of body fat percentage and TNF-α and higher values of the IL-10/TNF-α ratio were also observed. The higher IL-10/TNF-α ratio in the MS group is related to the greater anti-inflationary action of IL-10. The IL-10/TNF-α ratio showed significant accuracy to discriminate patients with MS according to the NCEP-ATP III criteria. |
| first_indexed | 2024-03-10T00:57:21Z |
| format | Article |
| id | doaj.art-132af76292944f7d89d9b0da994fb125 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T00:57:21Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-132af76292944f7d89d9b0da994fb1252023-11-23T14:40:35ZengMDPI AGMetabolites2218-19892022-01-011217310.3390/metabo12010073Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal WomenRenata Vargas Sinatora0Eduardo Federighi Baisi Chagas1Fernando Otavio Pires Mattera2Luciano Junqueira Mellem3Ana Rita de Oliveira dos Santos4Larissa Pires Pereira5Ana Luíza de Carvalho Aranão6Elen Landgraf Guiguer7Adriano Cressoni Araújo8Jesselina F. dos Santos Haber9Leila Campos Guissoni10Sandra Maria Barbalho11Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilInterdisciplinary Center on Diabetes (CENID), University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, SP, BrazilThe increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metabolic syndrome (MS) in postmenopausal women considering different diagnostic criteria. We conducted a cross-sectional observational study based on STROBE. Data were collected regarding the diagnostic criteria for MS (International Diabetes Federation; NCEP (International Diabetes Federation (IDF), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and Harmonized criteria), body composition, comorbidities, time without menstruation, values of IL-6, IL-10, and TNF-α. ANOVA, Kruskal–Wallis, Levene tests, ROC, and odds ratio were performed to analyze the data. The results showed no significant difference between the methods and no interaction between the method and the presence of MS. However, for the values of WC, body fat percentage, TNF-α, and IL-10/TNF-α ratio, a significant effect of MS was observed. In subjects with MS, lower values of body fat percentage and TNF-α and higher values of the IL-10/TNF-α ratio were also observed. The higher IL-10/TNF-α ratio in the MS group is related to the greater anti-inflationary action of IL-10. The IL-10/TNF-α ratio showed significant accuracy to discriminate patients with MS according to the NCEP-ATP III criteria.https://www.mdpi.com/2218-1989/12/1/73menopausevisceral fatinflammationIL-6IL10TNF-α |
| spellingShingle | Renata Vargas Sinatora Eduardo Federighi Baisi Chagas Fernando Otavio Pires Mattera Luciano Junqueira Mellem Ana Rita de Oliveira dos Santos Larissa Pires Pereira Ana Luíza de Carvalho Aranão Elen Landgraf Guiguer Adriano Cressoni Araújo Jesselina F. dos Santos Haber Leila Campos Guissoni Sandra Maria Barbalho Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women Metabolites menopause visceral fat inflammation IL-6 IL10 TNF-α |
| title | Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women |
| title_full | Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women |
| title_fullStr | Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women |
| title_full_unstemmed | Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women |
| title_short | Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women |
| title_sort | relationship of inflammatory markers and metabolic syndrome in postmenopausal women |
| topic | menopause visceral fat inflammation IL-6 IL10 TNF-α |
| url | https://www.mdpi.com/2218-1989/12/1/73 |
| work_keys_str_mv | AT renatavargassinatora relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT eduardofederighibaisichagas relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT fernandootaviopiresmattera relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT lucianojunqueiramellem relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT anaritadeoliveiradossantos relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT larissapirespereira relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT analuizadecarvalhoaranao relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT elenlandgrafguiguer relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT adrianocressoniaraujo relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT jesselinafdossantoshaber relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT leilacamposguissoni relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen AT sandramariabarbalho relationshipofinflammatorymarkersandmetabolicsyndromeinpostmenopausalwomen |