GALC deletions increase the risk of primary open-angle glaucoma: the role of Mendelian variants in complex disease.

GALC deletions increase the risk of primary open-angle glaucoma: the role of Mendelian variants in complex disease.

DNA copy number variants (CNVs) have been reported in many human diseases including autism and schizophrenia. Primary Open Angle Glaucoma (POAG) is a complex adult-onset disorder characterized by progressive optic neuropathy and vision loss. Previous studies have identified rare CNVs in POAG; howeve...

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Bibliographic Details
Main Authors:	Yutao Liu, Jason Gibson, Joshua Wheeler, Lydia Coulter Kwee, Cecile M Santiago-Turla, Stephen K Akafo, Paul R Lichter, Douglas E Gaasterland, Sayoko E Moroi, Pratap Challa, Leon W Herndon, Christopher A Girkin, Donald L Budenz, Julia E Richards, R Rand Allingham, Michael A Hauser
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3208571?pdf=render

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