Subependymal giant cell astrocytoma, report of a rare case
Tuberous sclerosis complex (TSC) is a rare genetic disease that is inherited autosomal dominantly and may be associated with subependymal giant cell astrocytoma (SEGA) in 10-20% of cases. Different phenotypes are related to the form of lesions in different parts of the body, including skin, brain,...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-02-01
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| Series: | Basic & Clinical Cancer Research |
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| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/419 |
| _version_ | 1797902769786454016 |
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| author | Behnaz Darvishi Negin Farhad Mazaher Ramezani |
| author_facet | Behnaz Darvishi Negin Farhad Mazaher Ramezani |
| author_sort | Behnaz Darvishi |
| collection | DOAJ |
| description |
Tuberous sclerosis complex (TSC) is a rare genetic disease that is inherited autosomal dominantly and may be associated with subependymal giant cell astrocytoma (SEGA) in 10-20% of cases. Different phenotypes are related to the form of lesions in different parts of the body, including skin, brain, kidneys, lungs, and heart. Age of patient, location of the tumor, and associated skin or neurological lesions may guide the pathologist for a definite diagnosis. Here we report a case of SEGA in an adolescent with TSC. Neurological clues including seizure and mental retardation, facial angiofibroma, renal mass, and histopathology examination of brain tumor culminated in the diagnosis of TSC and SEGA.
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| first_indexed | 2024-04-10T09:22:54Z |
| format | Article |
| id | doaj.art-132bd9b78c924487b6c371139eb4fd96 |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-04-10T09:22:54Z |
| publishDate | 2023-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-132bd9b78c924487b6c371139eb4fd962023-02-20T08:42:58ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662023-02-01141Subependymal giant cell astrocytoma, report of a rare caseBehnaz Darvishi0Negin Farhad1Mazaher Ramezani2Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranStudents Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Molecular Pathology, Kermanshah University of Medical Sciences, Kermansha, Iran Tuberous sclerosis complex (TSC) is a rare genetic disease that is inherited autosomal dominantly and may be associated with subependymal giant cell astrocytoma (SEGA) in 10-20% of cases. Different phenotypes are related to the form of lesions in different parts of the body, including skin, brain, kidneys, lungs, and heart. Age of patient, location of the tumor, and associated skin or neurological lesions may guide the pathologist for a definite diagnosis. Here we report a case of SEGA in an adolescent with TSC. Neurological clues including seizure and mental retardation, facial angiofibroma, renal mass, and histopathology examination of brain tumor culminated in the diagnosis of TSC and SEGA. https://bccr.tums.ac.ir/index.php/bccrj/article/view/419Subependymal giant cell astrocytoma, Tuberous sclerosis complex |
| spellingShingle | Behnaz Darvishi Negin Farhad Mazaher Ramezani Subependymal giant cell astrocytoma, report of a rare case Basic & Clinical Cancer Research Subependymal giant cell astrocytoma, Tuberous sclerosis complex |
| title | Subependymal giant cell astrocytoma, report of a rare case |
| title_full | Subependymal giant cell astrocytoma, report of a rare case |
| title_fullStr | Subependymal giant cell astrocytoma, report of a rare case |
| title_full_unstemmed | Subependymal giant cell astrocytoma, report of a rare case |
| title_short | Subependymal giant cell astrocytoma, report of a rare case |
| title_sort | subependymal giant cell astrocytoma report of a rare case |
| topic | Subependymal giant cell astrocytoma, Tuberous sclerosis complex |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/419 |
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