Correlation of the TIGIT-PVR immune checkpoint axis with clinicopathological features in triple-negative breast cancer

Correlation of the TIGIT-PVR immune checkpoint axis with clinicopathological features in triple-negative breast cancer

BackgroundT cell immunoreceptor with Ig and ITIM domains (TIGIT) interacts with poliovirus receptor (PVR) to contribute to cancer immune escape. Recently, TIGIT and PVR have been identified as promising immunotherapy targets. Their gene expression is upregulated in many solid tumors, but their prote...

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Bibliographic Details
Main Authors: Florence Boissière-Michot, Marie-Christine Chateau, Simon Thézenas, Séverine Guiu, Angélique Bobrie, William Jacot
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
TIGIT
T-cell immunoglobulin and ITIM domain
PVR (CD155)
triple negative breast cancer
immunohistochemistry
human tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058424/full

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