Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan
Current trends indicate a growing interest among healthcare specialists and the public in the use of regenerative medicine-based approaches for skin regeneration. The approaches are categorised in either cell-based or cell-free therapies and are reportedly safe and effective. Cell-based therapies in...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320422000517 |
| _version_ | 1811293741909016576 |
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| author | Yusuke Shimizu Edward Hosea Ntege Hiroshi Sunami |
| author_facet | Yusuke Shimizu Edward Hosea Ntege Hiroshi Sunami |
| author_sort | Yusuke Shimizu |
| collection | DOAJ |
| description | Current trends indicate a growing interest among healthcare specialists and the public in the use of regenerative medicine-based approaches for skin regeneration. The approaches are categorised in either cell-based or cell-free therapies and are reportedly safe and effective. Cell-based therapies include mesenchymal stem cells (MSCs), tissue induced pluripotent stem cells (iPSCs), fibroblast-based products, and blood-derived therapies, such as those employing platelet-rich plasma (PRP) products. Cell-free therapies primarily involve the use of MSC-derived extracellular vesicles/exosomes. MSCs are isolated from various tissues, such as fat, bone marrow, umbilical cord, menstrual blood, and foetal skin, and expanded ex vivo before transplantation. In cell-free therapies, MSC exosomes, MSC-derived cultured media, and MSC-derived extracellular vesicles are collected from MSC-conditioned media or supernatant. In this review, a literature search of the Cochrane Library, MEDLINE (PubMed), EMBASE, and Scopus was conducted using several combinations of terms, such as ‘stem’, ‘cell’, ‘aging’, ‘wrinkles’, ‘nasolabial folds’, ‘therapy’, ‘mesenchymal stem cells’, and ‘skin’, to identify relevant articles providing a comprehensive update on the different regenerative medicine-based therapies and their application to skin regeneration. In addition, the regulatory perspectives on the clinical application of some of these therapies in Japan are highlighted. |
| first_indexed | 2024-04-13T05:07:04Z |
| format | Article |
| id | doaj.art-132e017079e34dcea20e6ef27039b149 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-13T05:07:04Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-132e017079e34dcea20e6ef27039b1492022-12-22T03:01:09ZengElsevierRegenerative Therapy2352-32042022-12-01217380Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in JapanYusuke Shimizu0Edward Hosea Ntege1Hiroshi Sunami2Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, Japan; Corresponding author. Department of Plastic and Reconstructive Surgery Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, JapanCenter for Advanced Medical Research, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, JapanCurrent trends indicate a growing interest among healthcare specialists and the public in the use of regenerative medicine-based approaches for skin regeneration. The approaches are categorised in either cell-based or cell-free therapies and are reportedly safe and effective. Cell-based therapies include mesenchymal stem cells (MSCs), tissue induced pluripotent stem cells (iPSCs), fibroblast-based products, and blood-derived therapies, such as those employing platelet-rich plasma (PRP) products. Cell-free therapies primarily involve the use of MSC-derived extracellular vesicles/exosomes. MSCs are isolated from various tissues, such as fat, bone marrow, umbilical cord, menstrual blood, and foetal skin, and expanded ex vivo before transplantation. In cell-free therapies, MSC exosomes, MSC-derived cultured media, and MSC-derived extracellular vesicles are collected from MSC-conditioned media or supernatant. In this review, a literature search of the Cochrane Library, MEDLINE (PubMed), EMBASE, and Scopus was conducted using several combinations of terms, such as ‘stem’, ‘cell’, ‘aging’, ‘wrinkles’, ‘nasolabial folds’, ‘therapy’, ‘mesenchymal stem cells’, and ‘skin’, to identify relevant articles providing a comprehensive update on the different regenerative medicine-based therapies and their application to skin regeneration. In addition, the regulatory perspectives on the clinical application of some of these therapies in Japan are highlighted.http://www.sciencedirect.com/science/article/pii/S2352320422000517Skin regenerationSkin ageingMesenchymal stem cellsCell-based therapyCell-free therapyAutologous transplantation |
| spellingShingle | Yusuke Shimizu Edward Hosea Ntege Hiroshi Sunami Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan Regenerative Therapy Skin regeneration Skin ageing Mesenchymal stem cells Cell-based therapy Cell-free therapy Autologous transplantation |
| title | Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan |
| title_full | Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan |
| title_fullStr | Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan |
| title_full_unstemmed | Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan |
| title_short | Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan |
| title_sort | current regenerative medicine based approaches for skin regeneration a review of literature and a report on clinical applications in japan |
| topic | Skin regeneration Skin ageing Mesenchymal stem cells Cell-based therapy Cell-free therapy Autologous transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2352320422000517 |
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