α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

Abstract Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably undergoes extensive conformational metamorphoses and...

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Bibliographic Details
Main Authors: Christopher Simon, Tomoko Soga, Hirotaka James Okano, Ishwar Parhar
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cell & Bioscience
Subjects:
Alzheimer’s disease
Parkinson’s disease
Braak hypothesis
Oligomers
Fibrils
Online Access:https://doi.org/10.1186/s13578-021-00709-y

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