Radial Flow Perfusion Enables Real-Time Profiling of Cellular Metabolism at Low Oxygen Levels with Hyperpolarized <sup>13</sup>C NMR Spectroscopy

Radial Flow Perfusion Enables Real-Time Profiling of Cellular Metabolism at Low Oxygen Levels with Hyperpolarized <sup>13</sup>C NMR Spectroscopy

In this study, we describe new methods for studying cancer cell metabolism with hyperpolarized <sup>13</sup>C magnetic resonance spectroscopy (HP <sup>13</sup>C MRS) that will enable quantitative studies at low oxygen concentrations. Cultured hepatocellular carcinoma cells we...

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Bibliographic Details
Main Authors: Anthony Mancuso, Mehrdad Pourfathi, Ryan M. Kiefer, Michael C. Noji, Sarmad Siddiqui, Enri Profka, Charles N. Weber, Austin Pantel, Stephen J. Kadlecek, Rahim Rizi, Terence P. F. Gade
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Metabolites
Subjects:
hyperpolarized <sup>13</sup>C
DNP
NMR spectroscopy
radial flow
oxygen transport
perfusion
Online Access:https://www.mdpi.com/2218-1989/11/9/576

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