A unified method for detecting secondary trait associations with rare variants: application to sequence data.

A unified method for detecting secondary trait associations with rare variants: application to sequence data.

Next-generation sequencing has made possible the detection of rare variant (RV) associations with quantitative traits (QT). Due to high sequencing cost, many studies can only sequence a modest number of selected samples with extreme QT. Therefore association testing in individual studies can be unde...

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Bibliographic Details
Main Authors: Dajiang J Liu, Suzanne M Leal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3499373?pdf=render

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