Primary hypertrophic osteoarthropathy: genetics, clinical features and management

Primary hypertrophic osteoarthropathy: genetics, clinical features and management

Primary hypertrophic osteoarthropathy (PHO) is a genetic disorder mainly characterized by clubbing fingers, pachydermia and periostosis. Mutations in the HPGD or SLCO2A1 gene lead to impaired prostaglandin E2 (PGE2) degradation, thus elevating PGE2 levels. The identification of the causative genes h...

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Bibliographic Details
Main Authors: Qi Lu, Yang Xu, Zeng Zhang, Shanshan Li, Zhenlin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
Subjects:
primary hypertrophic osteoarthropathy
prostaglandin E2
NSAIDs
SLCO2A1 gene
HPGD gene
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1235040/full

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