GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

<p>Abstract</p> <p>Background</p> <p>Microglia are resident macrophage-like cells in the central nervous system (CNS) and cause innate immune responses via the LPS receptors, Toll-like receptor (TLR) 4 and CD14, in a variety of neuroinflammatory disorders including bact...

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Bibliographic Details
Main Authors: Parajuli Bijay, Sonobe Yoshifumi, Kawanokuchi Jun, Doi Yukiko, Noda Mariko, Takeuchi Hideyuki, Mizuno Tetsuya, Suzumura Akio
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
TLR4
CD14
GM-CSF
NF-κB
Online Access:http://www.jneuroinflammation.com/content/9/1/268

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