The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study
BackgroundPatients with Parkinson’s disease (PD) and sarcopenia often exhibit resilience, frailty, disability, and depression, highlighting the complex and interrelated nature of these conditions.ObjectiveDespite the presence of clinical manifestations of muscle atrophy in both PD and sarcopenia, ac...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1254859/full |
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| author | Minglei Chen Xiaofang Liu Qiuwan Liu Changwei Ding Ping Zhao Yingchun Zhang Chengjie Mao Chunfeng Liu Chunfeng Liu |
| author_facet | Minglei Chen Xiaofang Liu Qiuwan Liu Changwei Ding Ping Zhao Yingchun Zhang Chengjie Mao Chunfeng Liu Chunfeng Liu |
| author_sort | Minglei Chen |
| collection | DOAJ |
| description | BackgroundPatients with Parkinson’s disease (PD) and sarcopenia often exhibit resilience, frailty, disability, and depression, highlighting the complex and interrelated nature of these conditions.ObjectiveDespite the presence of clinical manifestations of muscle atrophy in both PD and sarcopenia, accurately discerning the coexistence of sarcopenia in PD patients remains a challenging task with significant implications for treatment strategies and prognostic assessments. This study aims to elucidate the specific ultrasonic diagnostic parameters associated with PD accompanied by sarcopenia through a comparative analysis of muscle ultrasound parameters in patients with PD, thereby presenting a novel approach for rapid identification of this condition.MethodsA total of 110 participants were enrolled in this study, including patients with PD and control subjects. Demographic data, clinical characteristics, physical performance tests, appendicular skeletal muscle mass index (ASMI), bioelectrical impedance analysis and muscle ultrasound measurements were collected from all participants. The muscle ultrasound measurements encompassed assessments of muscle thickness, pennation angle and shear wave elastography at various anatomical sites.ResultsParkinson’s disease patients exhibited decreased muscle strength and physical performance, and increased shear wave elastography value. In PD patients with sarcopenia, body circumference, including calf circumference, mid-arm circumference, Waist-to-Hip Ratio and body mass index (BMI) were all significantly decreased. Biceps brachii muscle thickness (MT) and gastrocnemius MT decreased in PD patients with sarcopenia and low ASMI. Binary logistic regression analysis revealed that male PD patients, BMI and gastrocnemius MT were predictive factors for ASMI in PD patients.ConclusionBiceps brachii MT and gastrocnemius MT are important indicators for distinguishing whether PD patients have sarcopenia. Male patients, low BMI and gastrocnemius MT were identified as valid predictors of low ASMI in PD patients. The findings of this study provide important insights into the use of muscle ultrasound in the diagnosis of PD with sarcopenia. |
| first_indexed | 2024-03-11T18:33:31Z |
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| language | English |
| last_indexed | 2024-03-11T18:33:31Z |
| publishDate | 2023-10-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-1335eb295766443e8d34b0a4815a1bfd2023-10-13T07:38:35ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-10-011710.3389/fnins.2023.12548591254859The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot studyMinglei Chen0Xiaofang Liu1Qiuwan Liu2Changwei Ding3Ping Zhao4Yingchun Zhang5Chengjie Mao6Chunfeng Liu7Chunfeng Liu8Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Neurology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, ChinaBackgroundPatients with Parkinson’s disease (PD) and sarcopenia often exhibit resilience, frailty, disability, and depression, highlighting the complex and interrelated nature of these conditions.ObjectiveDespite the presence of clinical manifestations of muscle atrophy in both PD and sarcopenia, accurately discerning the coexistence of sarcopenia in PD patients remains a challenging task with significant implications for treatment strategies and prognostic assessments. This study aims to elucidate the specific ultrasonic diagnostic parameters associated with PD accompanied by sarcopenia through a comparative analysis of muscle ultrasound parameters in patients with PD, thereby presenting a novel approach for rapid identification of this condition.MethodsA total of 110 participants were enrolled in this study, including patients with PD and control subjects. Demographic data, clinical characteristics, physical performance tests, appendicular skeletal muscle mass index (ASMI), bioelectrical impedance analysis and muscle ultrasound measurements were collected from all participants. The muscle ultrasound measurements encompassed assessments of muscle thickness, pennation angle and shear wave elastography at various anatomical sites.ResultsParkinson’s disease patients exhibited decreased muscle strength and physical performance, and increased shear wave elastography value. In PD patients with sarcopenia, body circumference, including calf circumference, mid-arm circumference, Waist-to-Hip Ratio and body mass index (BMI) were all significantly decreased. Biceps brachii muscle thickness (MT) and gastrocnemius MT decreased in PD patients with sarcopenia and low ASMI. Binary logistic regression analysis revealed that male PD patients, BMI and gastrocnemius MT were predictive factors for ASMI in PD patients.ConclusionBiceps brachii MT and gastrocnemius MT are important indicators for distinguishing whether PD patients have sarcopenia. Male patients, low BMI and gastrocnemius MT were identified as valid predictors of low ASMI in PD patients. The findings of this study provide important insights into the use of muscle ultrasound in the diagnosis of PD with sarcopenia.https://www.frontiersin.org/articles/10.3389/fnins.2023.1254859/fullParkinson’s diseasesarcopeniamuscular ultrasoundmuscle thicknessshear wave elastography |
| spellingShingle | Minglei Chen Xiaofang Liu Qiuwan Liu Changwei Ding Ping Zhao Yingchun Zhang Chengjie Mao Chunfeng Liu Chunfeng Liu The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study Frontiers in Neuroscience Parkinson’s disease sarcopenia muscular ultrasound muscle thickness shear wave elastography |
| title | The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study |
| title_full | The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study |
| title_fullStr | The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study |
| title_full_unstemmed | The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study |
| title_short | The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson’s disease with sarcopenia: a pilot study |
| title_sort | value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in parkinson s disease with sarcopenia a pilot study |
| topic | Parkinson’s disease sarcopenia muscular ultrasound muscle thickness shear wave elastography |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1254859/full |
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