Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort
Background: Studies have identified lifestyle risk factors for perinatal depression, but none have examined the cumulative effect of these risk factors in pregnant women. Methods: We considered the following six factors during pregnancy: poor diet quality (Healthy eating index for Singapore pregnant...
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| Language: | English |
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Elsevier
2020-11-01
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| Series: | Comprehensive Psychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X20300523 |
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| author | Linde van Lee Airu Chia Desiree Phua Marjorelee Colega Natarajan Padmapriya Jonathan Y. Bernard Shirong Cai Elaine K.H. Tham Oon Hoe Teoh Daniel Goh Joshua J. Gooley Peter D. Gluckman Fabian Yap Lynette P.C. Shek Keith M. Godfrey Kok Hian Tan Yap-Seng Chong Falk Müller-Riemenschneider Birit Broekman Michael Meaney Helen Chen Mary F.F. Chong |
| author_facet | Linde van Lee Airu Chia Desiree Phua Marjorelee Colega Natarajan Padmapriya Jonathan Y. Bernard Shirong Cai Elaine K.H. Tham Oon Hoe Teoh Daniel Goh Joshua J. Gooley Peter D. Gluckman Fabian Yap Lynette P.C. Shek Keith M. Godfrey Kok Hian Tan Yap-Seng Chong Falk Müller-Riemenschneider Birit Broekman Michael Meaney Helen Chen Mary F.F. Chong |
| author_sort | Linde van Lee |
| collection | DOAJ |
| description | Background: Studies have identified lifestyle risk factors for perinatal depression, but none have examined the cumulative effect of these risk factors in pregnant women. Methods: We considered the following six factors during pregnancy: poor diet quality (Healthy eating index for Singapore pregnant women<median), poor sleep quality (global Pittsburgh sleep quality index score > 5), physical inactivity (<600 MET-minutes/week), vitamin D insufficiency (<50 nmol/l), smoking before or during pregnancy, and the perceived need for social support. Probable depression was assessed using the Edinburgh postnatal depression scale during pregnancy (>15) and at three months postpartum (≥13). Prevalence risk ratios were calculated with Poisson regressions while adjusting for potential confounders. Results: Of 535 pregnant women, 207 (39%) had zero or one risk factor, 146 (27%) had two, 119 (22%) had three, 48 (9%) had four, and 15 (3%) had ≥5 risk factors at 26–28 weeks' gestation. These six lifestyle habits contributed to 32% of the variance in depressive symptoms during pregnancy. The prevalence of being probably depressed was 6.4 (95% CI 2.1, 19.8; ptrend < 0.001) for expecting women who had ≥4 risk factors compared to women who had ≤1 risk factor. No association was observed between the number of risk factors and depressive symptoms at 3 months postpartum (ptrend = 0.746). Conclusion: Pregnant women with ≥4 lifestyle risk factors showed a higher prevalence of depression during pregnancy, while no associations were observed for postpartum depression. Clinical trial registration: This cohort is registered under the Clinical Trials identifier NCT01174875;http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2 |
| first_indexed | 2024-12-14T14:42:26Z |
| format | Article |
| id | doaj.art-1337af0c1b814138bd29f0693fcf57b1 |
| institution | Directory Open Access Journal |
| issn | 0010-440X |
| language | English |
| last_indexed | 2024-12-14T14:42:26Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj.art-1337af0c1b814138bd29f0693fcf57b12022-12-21T22:57:22ZengElsevierComprehensive Psychiatry0010-440X2020-11-01103152210Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohortLinde van Lee0Airu Chia1Desiree Phua2Marjorelee Colega3Natarajan Padmapriya4Jonathan Y. Bernard5Shirong Cai6Elaine K.H. Tham7Oon Hoe Teoh8Daniel Goh9Joshua J. Gooley10Peter D. Gluckman11Fabian Yap12Lynette P.C. Shek13Keith M. Godfrey14Kok Hian Tan15Yap-Seng Chong16Falk Müller-Riemenschneider17Birit Broekman18Michael Meaney19Helen Chen20Mary F.F. Chong21Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, SingaporeDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, SingaporeDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Early Life Research On Later Health Unit, Centre for Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), National Institute of Health and Medical Research (Inserm), Villejuif, FranceSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, SingaporeDepartment of Paediatrics, KK Women's and Children's Hospital, SingaporeDepartment of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeCenter for Cognitive Neuroscience, Program in Neuroscience and behavioural disorders, Duke-NUS Medical School, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Liggins Institute, University of Auckland, Auckland, New ZealandDepartment of Paediatrics, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UKDuke-NUS Medical School, Singapore, Singapore; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeSaw Swee Hock School of Public Health, National University of Singapore, Singapore; Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Centre, Berlin, GermanySingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Psychiatry, Amsterdam UMC, location VUmc, VU University, Amsterdam, the Netherlands; Department of Psychiatry, Onze Lieve Vrouwe Gasthuis, Amsterdam, the NetherlandsSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Departments of Psychiatry and Neurology and Neurosurgery, McGill University, Montreal, CanadaDepartment of Psychological Medicine, KK Women's and Children's hospital, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore; Corresponding author at: Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #09-01Q, 117549, Singapore.Background: Studies have identified lifestyle risk factors for perinatal depression, but none have examined the cumulative effect of these risk factors in pregnant women. Methods: We considered the following six factors during pregnancy: poor diet quality (Healthy eating index for Singapore pregnant women<median), poor sleep quality (global Pittsburgh sleep quality index score > 5), physical inactivity (<600 MET-minutes/week), vitamin D insufficiency (<50 nmol/l), smoking before or during pregnancy, and the perceived need for social support. Probable depression was assessed using the Edinburgh postnatal depression scale during pregnancy (>15) and at three months postpartum (≥13). Prevalence risk ratios were calculated with Poisson regressions while adjusting for potential confounders. Results: Of 535 pregnant women, 207 (39%) had zero or one risk factor, 146 (27%) had two, 119 (22%) had three, 48 (9%) had four, and 15 (3%) had ≥5 risk factors at 26–28 weeks' gestation. These six lifestyle habits contributed to 32% of the variance in depressive symptoms during pregnancy. The prevalence of being probably depressed was 6.4 (95% CI 2.1, 19.8; ptrend < 0.001) for expecting women who had ≥4 risk factors compared to women who had ≤1 risk factor. No association was observed between the number of risk factors and depressive symptoms at 3 months postpartum (ptrend = 0.746). Conclusion: Pregnant women with ≥4 lifestyle risk factors showed a higher prevalence of depression during pregnancy, while no associations were observed for postpartum depression. Clinical trial registration: This cohort is registered under the Clinical Trials identifier NCT01174875;http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2http://www.sciencedirect.com/science/article/pii/S0010440X20300523Perinatal DepressionPregnancyLifestyle BehavioursDietPhysical ActivitySmoking |
| spellingShingle | Linde van Lee Airu Chia Desiree Phua Marjorelee Colega Natarajan Padmapriya Jonathan Y. Bernard Shirong Cai Elaine K.H. Tham Oon Hoe Teoh Daniel Goh Joshua J. Gooley Peter D. Gluckman Fabian Yap Lynette P.C. Shek Keith M. Godfrey Kok Hian Tan Yap-Seng Chong Falk Müller-Riemenschneider Birit Broekman Michael Meaney Helen Chen Mary F.F. Chong Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort Comprehensive Psychiatry Perinatal Depression Pregnancy Lifestyle Behaviours Diet Physical Activity Smoking |
| title | Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort |
| title_full | Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort |
| title_fullStr | Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort |
| title_full_unstemmed | Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort |
| title_short | Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort |
| title_sort | multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy findings from the gusto cohort |
| topic | Perinatal Depression Pregnancy Lifestyle Behaviours Diet Physical Activity Smoking |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X20300523 |
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