Epigenetic Alterations in Pancreatic Cancer Metastasis
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of pancreatic cancer. Genomic analyses of PDA specimens have identified the recurrent genetic mutations that drive PDA initi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/8/1082 |
| _version_ | 1797524556162793472 |
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| author | Sarah S. Wang Jihao Xu Keely Y. Ji Chang-Il Hwang |
| author_facet | Sarah S. Wang Jihao Xu Keely Y. Ji Chang-Il Hwang |
| author_sort | Sarah S. Wang |
| collection | DOAJ |
| description | Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of pancreatic cancer. Genomic analyses of PDA specimens have identified the recurrent genetic mutations that drive PDA initiation and progression. However, the underlying mechanisms that further drive PDA metastasis remain elusive. Despite many attempts, no recurrent genetic mutation driving PDA metastasis has been found, suggesting that PDA metastasis is driven by epigenetic fluctuations rather than genetic factors. Therefore, establishing epigenetic mechanisms of PDA metastasis would facilitate the development of successful therapeutic interventions. In this review, we provide a comprehensive overview on the role of epigenetic mechanisms in PDA as a critical contributor on PDA progression and metastasis. In particular, we explore the recent advancements elucidating the role of nucleosome remodeling, histone modification, and DNA methylation in the process of cancer metastasis. |
| first_indexed | 2024-03-10T08:59:06Z |
| format | Article |
| id | doaj.art-133868449b2545ad9be1220f1e0d5d5c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:59:06Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-133868449b2545ad9be1220f1e0d5d5c2023-11-22T06:54:31ZengMDPI AGBiomolecules2218-273X2021-07-01118108210.3390/biom11081082Epigenetic Alterations in Pancreatic Cancer MetastasisSarah S. Wang0Jihao Xu1Keely Y. Ji2Chang-Il Hwang3Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis, Davis, CA 95616, USADepartment of Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis, Davis, CA 95616, USADepartment of Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis, Davis, CA 95616, USADepartment of Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis, Davis, CA 95616, USAPancreatic cancer is the third leading cause of cancer-related deaths in the United States. Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of pancreatic cancer. Genomic analyses of PDA specimens have identified the recurrent genetic mutations that drive PDA initiation and progression. However, the underlying mechanisms that further drive PDA metastasis remain elusive. Despite many attempts, no recurrent genetic mutation driving PDA metastasis has been found, suggesting that PDA metastasis is driven by epigenetic fluctuations rather than genetic factors. Therefore, establishing epigenetic mechanisms of PDA metastasis would facilitate the development of successful therapeutic interventions. In this review, we provide a comprehensive overview on the role of epigenetic mechanisms in PDA as a critical contributor on PDA progression and metastasis. In particular, we explore the recent advancements elucidating the role of nucleosome remodeling, histone modification, and DNA methylation in the process of cancer metastasis.https://www.mdpi.com/2218-273X/11/8/1082pancreatic cancerepigeneticsmetastasisDNA methylation |
| spellingShingle | Sarah S. Wang Jihao Xu Keely Y. Ji Chang-Il Hwang Epigenetic Alterations in Pancreatic Cancer Metastasis Biomolecules pancreatic cancer epigenetics metastasis DNA methylation |
| title | Epigenetic Alterations in Pancreatic Cancer Metastasis |
| title_full | Epigenetic Alterations in Pancreatic Cancer Metastasis |
| title_fullStr | Epigenetic Alterations in Pancreatic Cancer Metastasis |
| title_full_unstemmed | Epigenetic Alterations in Pancreatic Cancer Metastasis |
| title_short | Epigenetic Alterations in Pancreatic Cancer Metastasis |
| title_sort | epigenetic alterations in pancreatic cancer metastasis |
| topic | pancreatic cancer epigenetics metastasis DNA methylation |
| url | https://www.mdpi.com/2218-273X/11/8/1082 |
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