Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review
Background: Drug desensitization allows for safe administration of a drug to a patient with a previous hypersensitivity reaction. Successful desensitization protocols have been described for different medications, including protocols for oncology patients. Few cases of desensitization to sorafenib a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/12/6/601 |
| _version_ | 1797240797566861312 |
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| author | Natasa Kusic Vesna Tomic Spiric Snezana Arandjelovic Aleksandra Peric Popadic Ivana Bozic Antic Milan Dimitrijevic Rada Miskovic Ljiljana Stefanovic Aleksandra Plavsic |
| author_facet | Natasa Kusic Vesna Tomic Spiric Snezana Arandjelovic Aleksandra Peric Popadic Ivana Bozic Antic Milan Dimitrijevic Rada Miskovic Ljiljana Stefanovic Aleksandra Plavsic |
| author_sort | Natasa Kusic |
| collection | DOAJ |
| description | Background: Drug desensitization allows for safe administration of a drug to a patient with a previous hypersensitivity reaction. Successful desensitization protocols have been described for different medications, including protocols for oncology patients. Few cases of desensitization to sorafenib and imatinib have been described in the literature so far. Objective: The objective of this paper is to describe the process of the sorafenib and imatinib drug hypersensitivity diagnosis and desensitization process in two patients. Methods: Two oncology patients who experienced non-immediate hypersensitivity reactions to sorafenib and imatinib underwent desensitization to these drugs. We designed a protocol for the first patient and used a modified protocol from the literature for the second patient. Results: By using a slow desensitization technique and gradual tapering of corticosteroids and antihistamines, both patients reached the target dose of the incriminated drug. Conclusions: Desensitization to sorafenib and imatinib can be an effective therapeutic option in patients with hypersensitivity to those medications, without alternative treatment options. |
| first_indexed | 2024-04-24T18:13:09Z |
| format | Article |
| id | doaj.art-133884af5ff746b3a6a45b785581a459 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-04-24T18:13:09Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-133884af5ff746b3a6a45b785581a4592024-03-27T13:43:33ZengMDPI AGHealthcare2227-90322024-03-0112660110.3390/healthcare12060601Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature ReviewNatasa Kusic0Vesna Tomic Spiric1Snezana Arandjelovic2Aleksandra Peric Popadic3Ivana Bozic Antic4Milan Dimitrijevic5Rada Miskovic6Ljiljana Stefanovic7Aleksandra Plavsic8Clinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaEuromedik Healthcare System, 11158 Belgrade, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaClinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, SerbiaBackground: Drug desensitization allows for safe administration of a drug to a patient with a previous hypersensitivity reaction. Successful desensitization protocols have been described for different medications, including protocols for oncology patients. Few cases of desensitization to sorafenib and imatinib have been described in the literature so far. Objective: The objective of this paper is to describe the process of the sorafenib and imatinib drug hypersensitivity diagnosis and desensitization process in two patients. Methods: Two oncology patients who experienced non-immediate hypersensitivity reactions to sorafenib and imatinib underwent desensitization to these drugs. We designed a protocol for the first patient and used a modified protocol from the literature for the second patient. Results: By using a slow desensitization technique and gradual tapering of corticosteroids and antihistamines, both patients reached the target dose of the incriminated drug. Conclusions: Desensitization to sorafenib and imatinib can be an effective therapeutic option in patients with hypersensitivity to those medications, without alternative treatment options.https://www.mdpi.com/2227-9032/12/6/601desensitizationdrug hypersensitivity reactionimatinibsorafenib |
| spellingShingle | Natasa Kusic Vesna Tomic Spiric Snezana Arandjelovic Aleksandra Peric Popadic Ivana Bozic Antic Milan Dimitrijevic Rada Miskovic Ljiljana Stefanovic Aleksandra Plavsic Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review Healthcare desensitization drug hypersensitivity reaction imatinib sorafenib |
| title | Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review |
| title_full | Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review |
| title_fullStr | Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review |
| title_full_unstemmed | Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review |
| title_short | Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review |
| title_sort | successful desensitization to sorafenib and imatinib a report of two cases and a literature review |
| topic | desensitization drug hypersensitivity reaction imatinib sorafenib |
| url | https://www.mdpi.com/2227-9032/12/6/601 |
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