Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information
Objectives: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been investigated to better detect recurrent tumors of malignant soft tissue sarcoma (STS), however, DCE-MRI is time-consuming and not available at all medical centers. This study aims to evaluate the feasibility of dual-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2022-05-01
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| Series: | Journal of the Belgian Society of Radiology |
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| Online Access: | https://www.jbsr.be/articles/2602 |
| _version_ | 1828333649703993344 |
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| author | Hye Min Son Hye Jin Yoo Sung Hwan Hong Ja Young Choi Hee Dong Chae |
| author_facet | Hye Min Son Hye Jin Yoo Sung Hwan Hong Ja Young Choi Hee Dong Chae |
| author_sort | Hye Min Son |
| collection | DOAJ |
| description | Objectives: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been investigated to better detect recurrent tumors of malignant soft tissue sarcoma (STS), however, DCE-MRI is time-consuming and not available at all medical centers. This study aims to evaluate the feasibility of dual-phase postcontrast MRI sequences (early 3D spoiled gradient-echo [GRE] and delayed fast spin-echo [FSE] T1WI) for the differentiation of recurrent tumor from nonneoplastic lesions. Materials and methods: A total of 297 patients under postoperative surveillance for malignant STS were included in this retrospective study and divided into three subgroups, as follows: group A, recurrent tumors (n = 82); group B, pseudomasses (n = 55); and group C, postoperative inflammation (n = 160). All MRI examinations included dual-phase post-contrast sequences. The contrast-to-noise ratio (CNR) and the signal-intensity ratio (SIR) were used to evaluate the degree of contrast enhancement in target lesions. ROC curve analysis was performed to assess the diagnostic performance for recurrent tumor. Results: In the early phase, all mean CNR and SIR values were significantly higher in group A (all, 'p' < 0.05). However, the difference of the CNR between early and delayed post-contrast MRI showed a significantly lesser increase in group A than in the other groups when muscle was used as the reference tissue ('p' = 0.026). A comparison of ROC curves showed that dual-phase MRI had significantly better diagnostic performance than conventional postcontrast MRI. Conclusion: The addition of an early postcontrast 3D GRE to conventional FSE-T1WI is useful to detect recurrent tumors by providing additional information on early enhancement. |
| first_indexed | 2024-04-13T21:22:52Z |
| format | Article |
| id | doaj.art-133a9af0aca54cfba630573b3df0bb76 |
| institution | Directory Open Access Journal |
| issn | 2514-8281 |
| language | English |
| last_indexed | 2024-04-13T21:22:52Z |
| publishDate | 2022-05-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of the Belgian Society of Radiology |
| spelling | doaj.art-133a9af0aca54cfba630573b3df0bb762022-12-22T02:29:25ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812022-05-01106110.5334/jbsr.26021487Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast InformationHye Min Son0Hye Jin Yoo1Sung Hwan Hong2Ja Young Choi3Hee Dong Chae4Yeungnam University medical centerSeoul National University HospitalProfessor, department of radiology, Seoul National University HospitalSeoul National University HospitalSeoul National University HospitalObjectives: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been investigated to better detect recurrent tumors of malignant soft tissue sarcoma (STS), however, DCE-MRI is time-consuming and not available at all medical centers. This study aims to evaluate the feasibility of dual-phase postcontrast MRI sequences (early 3D spoiled gradient-echo [GRE] and delayed fast spin-echo [FSE] T1WI) for the differentiation of recurrent tumor from nonneoplastic lesions. Materials and methods: A total of 297 patients under postoperative surveillance for malignant STS were included in this retrospective study and divided into three subgroups, as follows: group A, recurrent tumors (n = 82); group B, pseudomasses (n = 55); and group C, postoperative inflammation (n = 160). All MRI examinations included dual-phase post-contrast sequences. The contrast-to-noise ratio (CNR) and the signal-intensity ratio (SIR) were used to evaluate the degree of contrast enhancement in target lesions. ROC curve analysis was performed to assess the diagnostic performance for recurrent tumor. Results: In the early phase, all mean CNR and SIR values were significantly higher in group A (all, 'p' < 0.05). However, the difference of the CNR between early and delayed post-contrast MRI showed a significantly lesser increase in group A than in the other groups when muscle was used as the reference tissue ('p' = 0.026). A comparison of ROC curves showed that dual-phase MRI had significantly better diagnostic performance than conventional postcontrast MRI. Conclusion: The addition of an early postcontrast 3D GRE to conventional FSE-T1WI is useful to detect recurrent tumors by providing additional information on early enhancement.https://www.jbsr.be/articles/2602sarcomatumor recurrencemultiparametric mricontrast mediasurveillance imaging |
| spellingShingle | Hye Min Son Hye Jin Yoo Sung Hwan Hong Ja Young Choi Hee Dong Chae Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information Journal of the Belgian Society of Radiology sarcoma tumor recurrence multiparametric mri contrast media surveillance imaging |
| title | Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information |
| title_full | Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information |
| title_fullStr | Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information |
| title_full_unstemmed | Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information |
| title_short | Detection of Soft Tissue Sarcoma Recurrence: Feasibility of Ultrafast 3D Gradient-Echo Sequence in Addition to Conventional Contrast-Enhanced MRI to Provide Early-Phase Postcontrast Information |
| title_sort | detection of soft tissue sarcoma recurrence feasibility of ultrafast 3d gradient echo sequence in addition to conventional contrast enhanced mri to provide early phase postcontrast information |
| topic | sarcoma tumor recurrence multiparametric mri contrast media surveillance imaging |
| url | https://www.jbsr.be/articles/2602 |
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