SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway

SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway

Spinster homologue 2 (SPNS2), a transporter of S1P (sphingosine-1-phosphate), has been reported to mediate immune response, vascular development, and pathologic processes of diseases such as cancer via S1P signaling pathways. However, its biological functions and expression profile in colorectal can...

Full description

Bibliographic Details
Main Authors: Lei Lv, Qiyi Yi, Ying Yan, Fengmei Chao, Ming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
SPNS2
colorectal cancer (CRC)
PTEN/AKT
invasion
metastasis
epithelial–mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.682773/full

Similar Items

Similar Items