Interleukin-35 Regulates Immune Microenvironment of Autoimmune Hepatitis Through Inducing the Expansion of Myeloid-Derived Suppressor Cells

Interleukin-35 Regulates Immune Microenvironment of Autoimmune Hepatitis Through Inducing the Expansion of Myeloid-Derived Suppressor Cells

Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine of IL12 cytokine family, however, the role of IL-35 in patients with AIH and its effect on myeloid-derived suppressor cells (MDSCs) has not yet been analyzed. The expression of IL-35 subunits (p35 and EBI3) in liver tissues was quantified...

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Bibliographic Details
Main Authors:	Min Lian, Jun Zhang, Li Zhao, Xiang Chen, Yanshen Peng, Qixia Wang, Shengliang Chen, Xiong Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-11-01
Series:	Frontiers in Immunology
Subjects:	Interleukin-35 myeloid-derived suppressor cells autoimmune hepatitis nitric oxide (NO) hepatic immune microenvironment
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02577/full

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