Ebola virus disease: past, present and future
Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-05-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115303658 |
| _version_ | 1818483234816655360 |
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| author | Harish Rajak Deepak Kumar Jain Avineesh Singh Ajay Kumar Sharma Anshuman Dixit |
| author_facet | Harish Rajak Deepak Kumar Jain Avineesh Singh Ajay Kumar Sharma Anshuman Dixit |
| author_sort | Harish Rajak |
| collection | DOAJ |
| description | Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, Côte d’Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans. |
| first_indexed | 2024-12-10T11:57:40Z |
| format | Article |
| id | doaj.art-133e001d55fa4464a30f792a1c1360cf |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-10T11:57:40Z |
| publishDate | 2015-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-133e001d55fa4464a30f792a1c1360cf2022-12-22T01:49:43ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912015-05-015533734310.1016/S2221-1691(15)30365-8Ebola virus disease: past, present and futureHarish Rajak0Deepak Kumar Jain1Avineesh Singh2Ajay Kumar Sharma3Anshuman Dixit4Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) IndiaInstitute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) IndiaInstitute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) IndiaDepartment of Pharmacy, G.S.V.M., Medical College, Kanpur-208002, (UP) IndiaInstitute of Life Sciences, Bhubaneswar-751 001, (Orissa) IndiaEbola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, Côte d’Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans.http://www.sciencedirect.com/science/article/pii/S2221169115303658Ebola virus diseaseEbola haemorrhagic feverEbola virusFiloviridae |
| spellingShingle | Harish Rajak Deepak Kumar Jain Avineesh Singh Ajay Kumar Sharma Anshuman Dixit Ebola virus disease: past, present and future Asian Pacific Journal of Tropical Biomedicine Ebola virus disease Ebola haemorrhagic fever Ebola virus Filoviridae |
| title | Ebola virus disease: past, present and future |
| title_full | Ebola virus disease: past, present and future |
| title_fullStr | Ebola virus disease: past, present and future |
| title_full_unstemmed | Ebola virus disease: past, present and future |
| title_short | Ebola virus disease: past, present and future |
| title_sort | ebola virus disease past present and future |
| topic | Ebola virus disease Ebola haemorrhagic fever Ebola virus Filoviridae |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115303658 |
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