Protease-activated receptor 2 promotes clearance of Pseudomonas aeruginosa infection by inducing cAMP-Rac1 signaling in alveolar macrophages

Protease-activated receptor 2 promotes clearance of Pseudomonas aeruginosa infection by inducing cAMP-Rac1 signaling in alveolar macrophages

Efficient phagocytosis of pathogens by the innate immune system during infectious injury is vital for restoring tissue integrity. Impaired phagocytosis, such as in the case of infection with Pseudomonas aeruginosa, a broad-spectrum antibiotic-resistant Gram-negative bacterium, can lead to a life thr...

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Bibliographic Details
Main Authors: Sheikh Rayees, Jagdish Chandra Joshi, Bhagwati Joshi, Vigneshwaran Vellingiri, Somenath Banerjee, Dolly Mehta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
cAMP
Pseudomonas aeruginosa
alveolar macrophage
PAR2
Rac1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.874197/full

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